MRPL27 contributes to unfavorable overall survival and disease-free survival from cholangiocarcinoma patients.
MRPL27 contributes to unfavorable overall survival and disease-free survival from cholangiocarcinoma patients.
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MRPL27 导致胆管癌患者总体生存率和无病生存率不佳
DOI：
10.7150/ijms.50782
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发表时间：
2021
影响因子：
3.6
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Zhuang L;Meng Z;Yang Z
目的：本研究旨在研究MRPL 27在癌症基因组图谱（TCGA）数据库中胆管癌患者生存中的作用。方法：采用TCGA-CHOL检测MRPL 27基因表达，并结合临床资料进行分析。考克斯回归模型用于评估MRPL 27与胆管癌生存率之间的潜在联系。在Metascape和Gene Set Enrichment Analysis（GSEA）数据库中进行MRPL 27的富集分析。结果：36例胆管癌患者纳入分析。MRPL 27 mRNA在肝内胆管癌、远端胆管癌和肝门/肝门周围胆管癌组织中表达显著上调（均P < 0.01）。与具有低MRPL 27的那些相比，具有高MRPL 27的胆管癌患者具有更差的总生存期（OS）和无病生存期（DFS）（所有p < 0.05）。单因素和多因素考克斯模型分析表明，MRPL 27可能是胆管癌患者OS和DFS的危险因素（均P < 0.01）。生物信息学分析表明，MRPL 27主要参与线粒体翻译延伸、呼吸电子传递、ATP合成和线粒体内膜组装等过程。胆管癌患者中未筛查到MRPL 27突变。结论：MRPL 27在胆管癌中表达上调，可能与胆管癌患者的生存率有关。
Objective: This study aimed to investigate the roles of MRPL27 in survival from cholangiocarcinoma patients in The Cancer Genome Atlas (TCGA) database. Methods: In TCGA-CHOL profile, MRPL27 gene expression and clinical data were obtained. Cox regression models were used to evaluate the potential links between MRPL27 and cholangiocarcinoma survival. Enrichment analysis of MRPL27 was conducted in Metascape and Gene Set Enrichment Analysis (GSEA) databases. Results: 36 cholangiocarcinoma patients were included in this analysis. MRPL27 mRNA was significantly upregulated in tumor tissues in cholangiocarcinoma patients including intrahepatic, distal and hilar/perihilar cholangiocarcinoma cases (all p < 0.01). Cholangiocarcinoma patients with high MRPL27 had worse overall survival (OS) and disease-free survival (DFS) compared to those with low MRPL27 (all p < 0.05). Univariate and multivariate Cox models indicated that MRPL27 should be a risk factor for the OS and DFS in cholangiocarcinoma patients (both p < 0.01). Bioinformatic analysis revealed that MRPL27 mainly involved in the processes of mitochondrial translation elongation, respiratory electron transport, ATP synthesis, and inner mitochondrial membrane organization. No mutations of MRPL27 were screened in cholangiocarcinoma patients. Conclusion: Upregulated in tumors, MRPL27 contributes to unfavorable survival in cholangiocarcinoma patients.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
GEPIA：用于癌症和正常基因表达谱和交互式分析的网络服务器。
影响因子：
14.9
作者：
Tang Z;Li C;Kang B;Gao G;Li C;Zhang Z
通讯作者：
Zhang Z
影响因子：
2.6
作者：
HOLMSTROM, K;BRANDT, T;KALLESOE, T
通讯作者：
KALLESOE, T
影响因子：
--
作者：
Krasinskas, Alyssa M
通讯作者：
Krasinskas, Alyssa M
影响因子：
4.4
作者：
Braconi C;Patel T
通讯作者：
Patel T