The Molecular Epidemiology and Clinical Phylogenetics of Rhinoviruses Among Paediatric Cases in Sydney, Australia.
The Molecular Epidemiology and Clinical Phylogenetics of Rhinoviruses Among Paediatric Cases in Sydney, Australia.
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澳大利亚悉尼儿童鼻病毒的分子流行病学和临床系统发生学。
DOI：
10.1016/j.ijid.2021.06.046
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发表时间：
2021-09
影响因子：
8.4
通讯作者：
Kok, Jen
中科院分区：
文献类型：
--
作者：
Adam, Dillon Charles;Chen, Xin;Scotch, Matthew;MacIntyre, Chandini Raina;Dwyer, Dominic;Kok, Jen
鼻病毒（RV）是所有年龄组的所有急性呼吸道感染的最常见病原体，也是儿童的重大疾病负担。最近的研究表明，RV-A和RV-C物种与疾病严重程度增加有关。为了更好地了解儿童病例中RV物种和临床特征之间的潜在关联，本研究旨在使用贝叶斯系统发育方法整合遗传和流行病学数据。使用流行病学和系统发育方法，使用2006年至2009年期间从澳大利亚悉尼儿童（< 18岁）中采样的52株RV分离株的匹配数据集，揭示了RV物种和亚型与临床疾病严重程度之间的潜在关联。结果发现，与RV-A相比，RV-C更有可能从2岁以下的儿科病例中分离出来，尽管在记录的症状中没有观察到显著差异。年龄和VP 4/VP 2衣壳蛋白基因型之间的显著遗传性状相关性表明，亚型之间的感染性可能存在年龄特异性差异。这项研究增加了越来越多的关于RV的流行病学证据。改善对RV的监测和检测，包括常规的全基因组测序，可能会提高对RV物种和亚型的不同疾病结局的理解。未来的研究可能旨在确定与RV年龄特异性感染相关的特定遗传标记，这可能为RV的治疗实践和公共卫生监测提供信息。
Rhinoviruses (RV) represent the most common aetiological agent of all acute respiratory tract infections across all age groups and a significant burden of disease among children. Recent studies have shown that RV-A and RV-C species are associated with increased disease severity. In order to better understand the potential associations between RV species and clinical features among paediatric cases, this study aimed to integrate genetic and epidemiological data using Bayesian phylogenetic methods. Potential associations between RV species and subtypes, and clinical disease severity using a matched dataset of 52 RV isolates sampled from children (< 18 years) in Sydney, Australia, between 2006 and 2009 were uncovered using epidemiological and phylogenetic methods. It was found that RV-C was significantly more likely to be isolated from paediatric cases aged < 2 years compared with RV-A, although no significant differences in recorded symptoms were observed. Significant phylogenetic-trait associations between age and the VP4/VP2 capsid protein phylogeny suggest that age-specific variations in infectivity among subtypes may may be possible. This study adds to the growing body of epidemiological evidence concerning RV. Improving surveillance and testing for RV, including routine whole genome sequencing, may improve understanding of the varied disease outcomes of RV species and subtypes. Future studies could aim to identify specific genetic markers associated with age-specific infectivity of RV, which could inform treatment practices and public health surveillance of RV.
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影响因子：
3.7
作者：
Huang T;Wang W;Bessaud M;Ren P;Sheng J;Yan H;Zhang J;Lin X;Wang Y;Delpeyroux F;Deubel V
通讯作者：
Deubel V
影响因子：
14.2
作者：
Linder, Jodell E.;Kraft, David C.;Mohamed, Yassir;Lu, Zengqi;Heil, Luke;Tollefson, Sharon;Saville, Benjamin R.;Wright, Peter F.;Williams, John V.;Miller, E. Kathryn
通讯作者：
Miller, E. Kathryn
影响因子：
8.8
作者：
Gaunt, E. R.;Harvala, H.;Simmonds, P.
通讯作者：
Simmonds, P.
DOI：
10.1016/j.jcv.2015.10.024
发表时间：
2015-12
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Bruning AHL;Thomas XV;van der Linden L;Wildenbeest JG;Minnaar RP;Jansen RR;de Jong MD;Sterk PJ;van der Schee MP;Wolthers KC;Pajkrt D
通讯作者：
Pajkrt D
DOI：
10.1093/bioinformatics/bts199
发表时间：
2012-06-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Kearse M;Moir R;Wilson A;Stones-Havas S;Cheung M;Sturrock S;Buxton S;Cooper A;Markowitz S;Duran C;Thierer T;Ashton B;Meintjes P;Drummond A
通讯作者：
Drummond A