Clinical, virological and epidemiological characteristics of rhinovirus infections in early childhood: A comparison between non-hospitalised and hospitalised children.
Clinical, virological and epidemiological characteristics of rhinovirus infections in early childhood: A comparison between non-hospitalised and hospitalised children.
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DOI：
10.1016/j.jcv.2015.10.024
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Pajkrt D
中科院分区：
文献类型：
--
作者：
Bruning AHL;Thomas XV;van der Linden L;Wildenbeest JG;Minnaar RP;Jansen RR;de Jong MD;Sterk PJ;van der Schee MP;Wolthers KC;Pajkrt D
鼻病毒（RV）经常引起幼儿呼吸道感染。我们评估了RV感染的特征与临床结果的关系。在幼儿中，临床结果与RV种类或类型无关。RV疾病的预后更可能受到多种（宿主特异性）因素的影响。关于不同鼻病毒（RV）种（a型、b型和c型）的流行病学和临床意义，已经发表了几项研究。然而，关于幼儿RV类型及其与临床结果的关联的数据有限。在这里，我们调查了轻度或无症状感染的幼儿（非住院儿童）和入院的有症状的幼儿的RV感染的临床、病毒学和流行病学特征。本研究的目的是评估幼儿RV感染的不同特征与临床结果之间的关系。从荷兰出生队列（europa研究）和因呼吸道症状入院的住院儿童中回顾性选择感染rv的儿童。2009年11月至2012年12月期间，共从65名非住院儿童和49名住院儿童中抽取120份rv型样本。RV-A是两个种群的优势种，其次是RV-C。RV-B仅偶见。RV物种在非住院和住院儿童中的分布具有可比性。在需要入住icu的呼吸窘迫儿童中，RV物种的分布与未住院儿童没有显著差异。在未住院和住院的儿童中均未发现主要的RV类型。然而，住院儿童年龄更小，有更多的潜在疾病，RV负荷更高，细菌合并感染更频繁。幼童感染RV的临床结局与RV的种类或类型无关，但更可能受到多种（宿主特异性）因素的影响。
Rhinoviruses (RV) frequently cause respiratory tract infections in young children. We evaluated characteristics of RV infections in relation to clinical outcome. In young children clinical outcome was not related to RV species or types. Outcome of RV disease is more likely influenced by multiple (host-specific) factors. Several studies have been published regarding the epidemiology and clinical significance of the different rhinovirus (RV) species (-A, -B and -C). However, data on RV types and the associations with clinical outcome in young children are limited. Here, we investigated the clinical, virological and epidemiological characteristics of RV infections in young children with mild or asymptomatic infection (non-hospitalised children) and in symptomatic young children admitted to the hospital. The aim of this study was to evaluate associations between different characteristics of RV infections and clinical outcome in young children. RV-infected children were retrospectively selected from a Dutch birth cohort (EUROPA-study) and from hospitalised children admitted to the hospital because of respiratory symptoms. In total 120 RV-typed samples could be selected from 65 non-hospitalised and 49 hospitalised children between November 2009 and December 2012. RV-A was the predominant species in both study populations, followed closely by RV-C. RV-B was observed only sporadically. The distribution of the RV species was comparable in non-hospitalised and hospitalised children. In children with respiratory distress who required ICU-admission the distribution of RV species did not differ significantly from the non-hospitalised children. No predominant RV type was present in non-hospitalised nor hospitalised children. However, hospitalised children were younger, had more often an underlying illness, a higher RV load and more frequently a bacterial co-infection. Clinical outcome of RV infected young children was not related to RV species or types, but may more likely be influenced by multiple (host-specific) factors.
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DOI：
10.1099/vir.0.053686-0
发表时间：
2013-08
期刊：
The Journal of general virology
影响因子：
--
作者：
McIntyre CL;Knowles NJ;Simmonds P
通讯作者：
Simmonds P
DOI：
10.1183/09031936.00092410
发表时间：
2011-05
期刊：
The European respiratory journal
影响因子：
--
作者：
Bizzintino J;Lee WM;Laing IA;Vang F;Pappas T;Zhang G;Martin AC;Khoo SK;Cox DW;Geelhoed GC;McMinn PC;Goldblatt J;Gern JE;Le Souëf PN
通讯作者：
Le Souëf PN
影响因子：
14.2
作者：
Linder, Jodell E.;Kraft, David C.;Mohamed, Yassir;Lu, Zengqi;Heil, Luke;Tollefson, Sharon;Saville, Benjamin R.;Wright, Peter F.;Williams, John V.;Miller, E. Kathryn
通讯作者：
Miller, E. Kathryn
影响因子：
3.6
作者：
Jansen, Rogier R.;Schinkel, Janke;Pajkrt, Dasja
通讯作者：
Pajkrt, Dasja
影响因子：
3.5
作者：
McCulloch DJ;Sears MH;Jacob JT;Lyon GM;Burd EM;Caliendo AM;Hill CE;Nix WA;Oberste MS;Kraft CS
通讯作者：
Kraft CS