Insights into the genetic and host adaptability of emerging porcine circovirus 3.
Insights into the genetic and host adaptability of emerging porcine circovirus 3.
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DOI：
10.1080/21505594.2018.1492863
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发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Li G;Wang H;Wang S;Xing G;Zhang C;Zhang W;Liu J;Zhang J;Su S;Zhou J
猪圆环病毒3型（Porcine Circovirus 3，PCV 3）是一种与猪生殖系统疾病有关的病毒，自美国首次发现以来，已在世界范围内传播，尤其是在中国，对养猪业构成潜在威胁。然而，没有进行详尽的分析，以了解其进化的密码子使用模式的前景。在这里，我们对PCV 3进行了深入的密码子使用分析。PCV3基因序列经主成分分析可分为PCV3a和PCV3b两个分支。此外，PCV3的密码子使用偏倚程度略低，这是从有效密码子数分析推断的。密码子的使用模式主要受自然选择的影响，但也有突变压力和二核苷酸频率的共同作用。此外，通过相似性指数、密码子适应指数和相对密码子去优化指数分析，发现PCV3虽然致病性尚不清楚，但可能对公众健康构成潜在风险。总之，这项工作加强了对PCV 3进化的系统理解，这反映在这种新出现的病毒的密码子使用模式和适应性上。
Porcine circovirus 3 (PCV3) was found to be associated with reproductive disease in pigs, and since its first identification in the United States, it subsequently spread worldwide, especially in China, where it might pose a potential threat to the porcine industry. However, no exhaustive analysis was performed to understand its evolution in the prospect of codon usage pattern. Here, we performed a deep codon usage analysis of PCV3. PCV3 sequences were classified into two clades: PCV3a and PCV3b, confirmed by principal component analysis. Additionally, the degree of codon usage bias of PCV3 was slightly low as inferred from the analysis of the effective number of codons. The codon usage pattern was mainly affected by natural selection, but there was a co-effect of mutation pressure and dinucleotide frequency. Moreover, based on similarity index analysis, codon adaptation index analysis and relative codon deoptimization index analysis, we found that PCV3 might pose a potential risk to public health though with unknow pathogenicity. In conclusion, this work reinforces the systematic understanding of the evolution of PCV3, which was reflected by the codon usage patterns and fitness of this novel emergent virus.
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影响因子：
5
作者：
Gu W;Zhou T;Ma J;Sun X;Lu Z
通讯作者：
Lu Z
影响因子：
4.3
作者：
Chen, G. H.;Mai, K. J.;Ma, J. Y.
通讯作者：
Ma, J. Y.
影响因子：
4.3
作者：
Fu, X.;Fang, B.;Zhang, G.
通讯作者：
Zhang, G.
寨卡病毒基因组中密码子使用的演变是宿主和载体特异性的。
影响因子：
13.2
作者：
Butt, Azeem Mehmood;Nasrullah, Izza;Qamar, Raheel;Tong, Yigang
通讯作者：
Tong, Yigang
影响因子：
10.7
作者：
Holmes, EC;Worobey, M;Rambaut, A
通讯作者：
Rambaut, A