Concept of an upright wearable positron emission tomography imager in humans.
Concept of an upright wearable positron emission tomography imager in humans.
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DOI：
10.1002/brb3.530
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发表时间：
2016-09
影响因子：
3.1
通讯作者：
Majewski, Stan
中科院分区：
文献类型：
--
作者：
Bauer, Christopher E.;Brefczynski-Lewis, Julie;Marano, Gary;Mandich, Mary-Beth;Stolin, Alexander;Martone, Peter;Lewis, James W.;Jaliparthi, Gangadhar;Raylman, Raymond R.;Majewski, Stan
关键词：
正电子发射断层扫描（PET）传统上用于对处于限制性位置的患者进行成像，很少有设备允许直立的脑部专用成像。我们的团队已经探索了可穿戴PET成像仪的概念，它可以为自由移动的受试者提供功能性大脑成像。为了测试可行性并确定未来的开发考虑因素，我们构建了一个基本的概念验证原型（Helmet_PET），并在幻影和四名人类志愿者中进行了测试。十二个基于硅光电倍增管的探测器被组装在一个环中，该环具有外部重量支撑和可以可调节地安装到头部的内部机构。我们进行了脑体模测试，并扫描了4名计划进行诊断性F18‐ FDG PET/CT成像的患者。对于人类受试者，成像仪的角度应使视野包括基底神经节和视觉皮层，以测试典型的静息状态模式。两名受试者在PET/CT成像后约4小时进行成像，以利用示踪剂的天然放射性衰变（F18半衰期为110分钟）模拟较低的F18-FDG注射剂量，估计成像剂量为标准剂量的25%。我们发现，成像与一个简单的轻量级环的探测器是可行的，使用一小部分的标准放射性配体剂量。在一组解剖ROI中，人类参与者的活动水平在数量上与标准PET相似。即使在1分钟的主动头部旋转扫描中，也证明了典型的静息状态大脑模式激活。据我们所知，这是第一次演示用一种新型的可穿戴PET成像仪对人类受试者进行成像，这种成像仪随着头部的运动而运动。我们讨论了潜在的研究和临床应用，这将推动一个功能齐全的设备的设计。设计需要考虑在具有高移动性的低重量设备和具有更高灵敏度和更大视野的较重设备之间进行权衡。
Positron Emission Tomography (PET) is traditionally used to image patients in restrictive positions, with few devices allowing for upright, brain‐dedicated imaging. Our team has explored the concept of wearable PET imagers which could provide functional brain imaging of freely moving subjects. To test feasibility and determine future considerations for development, we built a rudimentary proof‐of‐concept prototype (Helmet_PET) and conducted tests in phantoms and four human volunteers. Twelve Silicon Photomultiplier‐based detectors were assembled in a ring with exterior weight support and an interior mechanism that could be adjustably fitted to the head. We conducted brain phantom tests as well as scanned four patients scheduled for diagnostic F18‐ FDG PET/CT imaging. For human subjects the imager was angled such that field of view included basal ganglia and visual cortex to test for typical resting‐state pattern. Imaging in two subjects was performed ~4 hr after PET/CT imaging to simulate lower injected F18‐ FDG dose by taking advantage of the natural radioactive decay of the tracer (F18 half‐life of 110 min), with an estimated imaging dosage of 25% of the standard. We found that imaging with a simple lightweight ring of detectors was feasible using a fraction of the standard radioligand dose. Activity levels in the human participants were quantitatively similar to standard PET in a set of anatomical ROIs. Typical resting‐state brain pattern activation was demonstrated even in a 1 min scan of active head rotation. To our knowledge, this is the first demonstration of imaging a human subject with a novel wearable PET imager that moves with robust head movements. We discuss potential research and clinical applications that will drive the design of a fully functional device. Designs will need to consider trade‐offs between a low weight device with high mobility and a heavier device with greater sensitivity and larger field of view.
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影响因子：
5.7
作者：
Villien M;Wey HY;Mandeville JB;Catana C;Polimeni JR;Sander CY;Zürcher NR;Chonde DB;Fowler JS;Rosen BR;Hooker JM
通讯作者：
Hooker JM
影响因子：
9.3
作者：
van Velden, Floris H. P.;Kloet, Reina W.;Boellaard, Ronald
通讯作者：
Boellaard, Ronald
DOI：
10.1111/j.1749-6632.1985.tb37596.x
发表时间：
1985-01-01
影响因子：
5.2
作者：
MAZZIOTTA, JC
通讯作者：
MAZZIOTTA, JC
影响因子：
1.8
作者：
Vaska, P;Woody, CL;Fontaine, R
通讯作者：
Fontaine, R
影响因子：
48
作者：
Schulz, Daniela;Southekal, Sudeepti;Vaska, Paul
通讯作者：
Vaska, Paul