Alcohol consumption and breast cancer oestrogen and progesterone receptor status.
Alcohol consumption and breast cancer oestrogen and progesterone receptor status.
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DOI：
10.1038/sj.bjc.6690210
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发表时间：
1999-03
影响因子：
8.8
通讯作者：
Bernstein, L
中科院分区：
文献类型：
--
作者：
Enger, SM;Ross, RK;Paganini-Hill, A;Longnecker, MP;Bernstein, L
我们使用在美国洛杉矶县进行的两项病例对照研究的数据，通过肿瘤的联合雌激素受体（ER）和孕激素受体（PR）状态来研究酒精对乳腺癌风险的作用。合格的绝经前患者为733例年龄≤ 40岁的女性，首次诊断时间为1983年7月1日至1989年1月1日。符合条件的绝经后患者为1169名年龄55-64岁的女性，首次诊断时间为1987年3月1日至1989年12月31日。患者由南加州大学癌症监测项目确定。根据产次（绝经前患者）和出生日期（± 3岁），将邻居对照与患者单独匹配。ER和PR状态从424例绝经前和760例绝经后患者的病历中获得。分析包括714名绝经前和1091名绝经后对照受试者。无论乳腺癌受体状态如何，饮酒通常与绝经前乳腺癌风险无关。在绝经后女性中，平均每天饮酒≥ 27 g的女性相对于未报告饮酒的女性，ER阳性/PR阳性乳腺癌的比值比（OR）为1.76 [95%置信区间（CI）1.14-2.71]。在绝经后女性中，饮酒与其他受体类型风险的相关性不太明显。这些数据表明，酒精可能优先增加绝经后妇女ER阳性/PR阳性乳腺癌的风险。© 1999癌症研究运动
We examined the role of alcohol on the risk of breast cancer by the joint oestrogen receptor (ER) and progesterone receptor (PR) status of the tumour using data from two case-control studies conducted in Los Angeles County, USA. Eligible premenopausal patients were 733 women aged ≤ 40 years and first diagnosed from 1 July 1983 to 1 January 1989. Eligible postmenopausal patients were 1169 women aged 55–64 years and first diagnosed from 1 March 1987 to 31 December 89. Patients were identified by the University of Southern California Cancer Surveillance Program. Neighbourhood controls were individually matched to patients by parity (premenopausal patients) and birth date (± 3 years). ER and PR status were obtained from medical records for 424 premenopausal and 760 postmenopausal patients. The analyses included 714 premenopausal and 1091 postmenopausal control subjects. Alcohol use was generally not associated with premenopausal risk of breast cancer, regardless of hormone-receptor status. Among the postmenopausal women, those who consumed, on average, ≥ 27 g of alcohol/d experienced an odds ratio (OR) of 1.76 [95% confidence interval (CI) 1.14–2.71] for ER-positive/PR-positive breast cancer relative to women who reported no alcohol consumption. Alcohol use was less clearly associated with risk of other receptor types among postmenopausal women. These data suggest that alcohol may preferentially increase risk of ER-positive/PR-positive breast cancer in postmenopausal women. © 1999 Cancer Research Campaign
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影响因子：
8.8
作者：
Cooper, J A;Rohan, T E;Cant, E L;Horsfall, D J;Tilley, W D
通讯作者：
Tilley, W D
影响因子：
2.3
作者：
DORGAN, JF;REICHMAN, ME;TAYLOR, PR
通讯作者：
TAYLOR, PR
DOI：
10.15288/jsa.1987.48.287
发表时间：
1987-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
MENDELSON, JH;MELLO, NK;SCHIFF, I
通讯作者：
SCHIFF, I
影响因子：
3.8
作者：
Romain, S;Spyratos, F;Magdelenat, H
通讯作者：
Magdelenat, H
影响因子：
8.4
作者：
ROMAIN, S;BIDRON, CL;MAGDELENAT, H
通讯作者：
MAGDELENAT, H