No association between 5-HTTLPR and harm avoidance in Korean college students.

No association between 5-HTTLPR and harm avoidance in Korean college students.
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DOI:
10.3346/jkms.2007.22.1.138
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发表时间:
2007-02
影响因子:
4.5
通讯作者:
Kim CY
Kim CY
中科院分区:
医学4区
文献类型:
--
作者:
Joo YH;Oh HB;Kim B;Jung SH;Chung JK;Hong JP;Kim CY

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关于 5-HTTLPR(血清素转运蛋白基因启动子区域的多态性)与焦虑相关人格特质之间的关联,已有大量研究,但结果相互矛盾。在这项研究中,我们对 158 名韩国大学生样本进行了韩国版气质和性格调查表 (K-TCI),并进行了 5-HTTLPR 基因分型,以便根据 5-HTTLPR 基因型和性别比较包括避免伤害在内的 TCI 维度得分。我们无法找到 5-HTTLPR 与避免伤害和其他 TCI 措施之间的关联。考虑到不同种族之间已知的 5-HTTLPR 等位基因频率差异,需要进一步进行更大样本的跨文化研究。
There have been numerous studies on the association between 5-HTTLPR (polymorphisms in the promoter region of the serotonin transporter gene) and anxiety-related personality traits, with conflicting results. In this study, we administered Korean version of the Temperament and Character Inventory (K-TCI) to a sample of 158 Korean college students and genotyped for the 5-HTTLPR in order to compare the TCI dimensional scores including harm avoidance according to the 5-HTTLPR genotype and sex. We could not find the association between 5-HTTLPR and harm avoidance and other TCI measures. Considering known allele frequencies differences of 5-HTTLPR among different ethnic groups, further cross-cultural studies with a larger sample would be needed.
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