Titanium immobilized with an antimicrobial peptide derived from histatin accelerates the differentiation of osteoblastic cell line, MC3T3-E1.
Titanium immobilized with an antimicrobial peptide derived from histatin accelerates the differentiation of osteoblastic cell line, MC3T3-E1.
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DOI：
10.3390/ijms11041458
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发表时间：
2010-04-02
影响因子：
5.6
通讯作者：
Tsuji K
中科院分区：
文献类型：
--
作者：
Makihira S;Shuto T;Nikawa H;Okamoto K;Mine Y;Takamoto Y;Ohara M;Tsuji K
本研究的目的是评估固定有来自组胺素的阳离子抗菌肽（JH 8194）的钛对牙龈卟啉单胞菌生物膜形成和成骨细胞（MC 3 T3-E1）分化的影响。按照上述方法，用JH 8194固定钛试样（Ti）。牙龈卟啉单胞菌在JH 8194-Ti上的定殖率显著低于对照Ti和封闭Ti。与对照组和阻断组相比，JH 8194-Ti可增强MC 3 T3-E1中Runx 2和OPN的mRNA表达，以及ALcase活性。这些结果综合起来表明，JH 8194-Ti可能是缩短获得骨整合时间的潜在辅助物。
The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.
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DOI：
10.1111/j.1708-8208.2000.tb00103.x
发表时间：
2000-01-01
影响因子：
3.6
作者：
Esposito, M;Thomsen, P;Lekholm, U
通讯作者：
Lekholm, U
影响因子：
5.5
作者：
NIKAWA, H;SADAMORI, S;OKUDA, K
通讯作者：
OKUDA, K
影响因子：
4.3
作者：
Schliephake, H;Aref, A;Sewing, A
通讯作者：
Sewing, A
影响因子：
3
作者：
Stallmann, HP;Faber, C;Wuisman, PIJM
通讯作者：
Wuisman, PIJM
DOI：
10.1002/jbm.1265
发表时间：
2002-03-05
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Becker, D;Geissler, U;Wenzel, KW
通讯作者：
Wenzel, KW