Insula-Retrosplenial Cortex Overconnectivity Increases Internalizing via Reduced Insight in Autism.
Insula-Retrosplenial Cortex Overconnectivity Increases Internalizing via Reduced Insight in Autism.
复制标题
岛叶-压后皮层过度连接通过减少自闭症的洞察力来增加内化。
DOI：
10.1016/j.biopsych.2018.01.015
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发表时间：
2018-08-15
影响因子：
10.6
通讯作者：
Solomon M
中科院分区：
文献类型：
--
作者：
Hogeveen J;Krug MK;Elliott MV;Solomon M
焦虑和抑郁等内化症状在自闭症谱系障碍 (ASD) 中很常见并且会受到损害。在这里，我们测试了以下假设：三个大脑网络 [显着网络 (SN)、默认模式网络 (DMN) 和额顶网络 (FPN)] 之间的异常功能连接在 ASD 内化的病理生理学中发挥作用。我们研究了 102 名患有 ASD（N=49）或典型发育（TYP；N=53）的青少年和年轻人的静息状态功能连接和内化之间的关联。使用最近的人类大脑皮层分割来对比 ASD 和 TYP 之间的种子到目标的功能连接，并根据父母报告的内化症状对 ASD 中异常的连接进行维度分析。 ASD 中的三个连接表现出强大的过度连接：i）前岛叶到压后皮质（即 SN-DMN），ii）前岛叶到额极（即 SN-FPN），以及 iii）背外侧前额叶皮质到压后皮质（即 FPN-DMN）。在控制年龄后，这些差异仍然显着，并且校正后没有与年龄相关的影响。 SN-DMN 连接与 ASD 中更大的内化有关，这是由自我报告的内化和父母报告的内化之间更大的差异介导的。对照分析发现，其他两个连接与内化无关，并且 SN-DMN 连接与良好匹配的控制措施（外化症状）无关。目前的研究结果为 SN-DMN 过度连接与 ASD 内化之间的特定联系提供了新的证据。此外，调解结果表明，完整的前岛叶-后压区连接可能在深入了解自己的精神病理学方面发挥作用。
Internalizing symptoms like anxiety and depression are common and impairing in autism spectrum disorder (ASD). Here, we test the hypothesis that aberrant functional connectivity between three brain networks [salience network (SN), default-mode network (DMN), and frontoparietal network (FPN)] plays a role in the pathophysiology of internalizing in ASD. We examined the association between resting-state functional connectivity and internalizing in 102 adolescents and young adults with ASD (N=49) or typical development (TYP; N=53). Seed-to-target functional connectivity was contrasted between ASD and TYP using a recent parcellation of the human cerebral cortex, and connections that were aberrant in ASD were analyzed dimensionally as a function of parent-reported internalizing symptoms. Three connections demonstrated robust overconnectivity in ASD: i) anterior insula to retrosplenial cortex (i.e. SN-DMN), ii) anterior insula to frontal pole (i.e. SN-FPN), and iii) dorsolateral prefrontal cortex to retrosplenial cortex (i.e. FPN-DMN). These differences remained significant after controlling for age, and no age-related effects survived correction. The SN-DMN connection was associated with greater internalizing in ASD, mediated by a bigger difference between self- and parent-reported internalizing. Control analyses found that the other two connections were not associated with internalizing, and SN-DMN connectivity was not associated with a well-matched control measure (externalizing symptoms). The present findings provide novel evidence for a specific link between SN-DMN overconnectivity and internalizing in ASD. Further, the mediation results suggest that intact anterior insula-retrosplenial connectivity may play a role in generating insight into ones’ own psychopathology.
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