emPHasis-10: development of a health-related quality of life measure in pulmonary hypertension.
emPHasis-10: development of a health-related quality of life measure in pulmonary hypertension.
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DOI：
10.1183/09031936.00127113
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Armstrong I
中科院分区：
文献类型：
--
作者：
Yorke J;Corris P;Gaine S;Gibbs JS;Kiely DG;Harries C;Pollock V;Armstrong I
本研究的目的是开发一种测量肺动脉高压（PH）对健康相关生活质量（HRQoL）的影响的方法，因为需要一种可用于常规临床实践的简短、经验证的工具。对30名PH患者进行了访谈，得出32个陈述，这些陈述以语义差异六点量表（0-5）的形式呈现，每端都有对比形容词。该项目列表由在英国和爱尔兰的PH诊所就诊的患者完成。应用Rasch分析来确定符合一维模型的项目。226例PH患者（平均年龄55.6±14岁; 70%为女性）（82%患有肺动脉高压）完成了研究问卷。32个项目中的10个证明符合Rasch模型（卡方16; p>0.05），并生成emPHasis-10问卷。重测（组内相关系数0.95，n=33）和内部一致性（Chronbach α=0.9）很强。emPHasis-10评分与其他相关指标和按世界卫生组织功能分类分层的患者区分亚组一致相关（ANOVA F=1.73; p<0.001）。emPHasis-10是用于评估肺动脉高压HRQoL的简短问卷。它具有出色的测量特性，对相关临床参数的差异敏感。它可免费供临床和学术使用。emPHasis-10是肺动脉高压患者健康相关生活质量常规评估的简短有效工具http://ow.ly/qv75v
The aim of this study was to develop a measure of the impact of pulmonary hypertension (PH) on health-related quality of life (HRQoL) as there is a need for a short, validated instrument that can be used in routine clinical practice. Interviews were conducted with 30 PH patients to derive 32 statements, which were presented as a semantic differential six-point scale (0–5), with contrasting adjectives at each end. This item list was completed by patients attending PH clinics across the UK and Ireland. Rasch analysis was applied to identify items fitting a uni-dimensional model. 226 patients (mean age 55.6±14 years; 70% female) with PH (82% had pulmonary arterial hypertension) completed the study questionnaires. 10 of the 32 items demonstrated fit to the Rasch model (Chi-squared 16; p>0.05) and generated the emPHasis-10 questionnaire. Test–retest (intraclass correlation coefficient 0.95, n=33) and internal consistency (Chronbach’s α=0.9) were strong. emPHasis-10 scores correlated consistently with other relevant measures and discriminated subgroups of patients stratified by World Health Organization functional class (ANOVA F=1.73; p<0.001). The emPHasis-10 is a short questionnaire for assessing HRQoL in pulmonary arterial hypertension. It has excellent measurement properties and is sensitive to differences in relevant clinical parameters. It is freely available for clinical and academic use. emPHasis-10 is a short, valid tool for routine assessment of health-related quality of life in pulmonary hypertension http://ow.ly/qv75v
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