Exposure to polychlorinated biphenyl (PCB) congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50.
Exposure to polychlorinated biphenyl (PCB) congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50.
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DOI：
10.1007/s10549-012-2257-4
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发表时间：
2012-11
影响因子：
3.8
通讯作者：
Cirillo, Piera M.
中科院分区：
文献类型：
--
作者：
Cohn, Barbara A.;Terry, Mary Beth;Plumb, Marj;Cirillo, Piera M.
已经确定了乳房对有毒物质的易感性的离散窗口，包括子宫内、青春期、妊娠期和产后。我们检验了这样的假设：产后早期测量的多氯联苯 (PCB) 可以预测 50 岁之前母亲患乳腺癌的风险增加。我们在儿童健康与发展研究队列的一项嵌套病例对照研究中，分析了 1959 年至 1967 年（平均诊断年龄 43 岁）收集的早期产后血清样本中的 16 种 PCB 同系物。 （N = 112 例与出生年份的对照相匹配）。我们使用条件逻辑回归来调整血脂、种族、年份、哺乳期和体重。我们观察到乳腺癌与三种同源物有很强的相关性。 PCB 167 与较低的风险相关（比值比 (OR)，第 75 个百分位数与第 25 个百分位数 = 0.2，95% 置信区间 (95% CI) 0.1, 0.8），PCB 187 也是如此（OR，第 75 个百分位数与第 25 个百分位数 = 0.4，95% CI 0.1, 1.1）。相比之下，PCB 203 与风险增加六倍相关（OR，第 75 个百分位数与第 25 个百分位数 = 6.3，95% CI 1.9、21.7）。根据事后评分估计，PCB 203 比例相对于 PCB 167 和 187 总和较高的女性中，PCB 暴露的净关联风险增加了近三倍（OR，第 75 个百分位数与第 25 个百分位数 = 2.8，95% CI 1.1，7.1）。产后 PCB 暴露也可能代表怀孕期间的暴露，并且可以预测早期乳腺癌的风险增加，具体取决于代表的混合物内部 剂量。目前尚不清楚暴露的个体差异、对暴露的反应或两者都解释了观察到的风险模式。
Discrete windows of susceptibility to toxicants have been identified for the breast, including in utero, puberty, pregnancy, and postpartum. We tested the hypothesis that polychlorinated biphenyls (PCBs) measured during the early postpartum predict increased risk of maternal breast cancer diagnosed before age 50. We analyzed archived early postpartum serum samples collected from 1959 to 1967, an average of 17 years before diagnosis (mean diagnosis age 43 years) for 16 PCB congeners in a nested case–control study in the Child Health and Development Studies cohort (N = 112 cases matched to controls on birth year). We used conditional logistic regression to adjust for lipids, race, year, lactation, and body mass. We observed strong breast cancer associations with three congeners. PCB 167 was associated with a lower risk (odds ratio (OR), 75th vs. 25th percentile = 0.2, 95 % confidence interval (95 % CI) 0.1, 0.8) as was PCB 187 (OR, 75th vs. 25th percentile = 0.4, 95 % CI 0.1, 1.1). In contrast, PCB 203 was associated with a sixfold increased risk (OR, 75th vs. 25th percentile = 6.3, 95 % CI 1.9, 21.7). The net association of PCB exposure, estimated by a post-hoc score, was nearly a threefold increase in risk (OR, 75th vs. 25th percentile = 2.8, 95 % CI 1.1, 7.1) among women with a higher proportion of PCB 203 in relation to the sum of PCBs 167 and 187. Postpartum PCB exposure likely also represents pregnancy exposure, and may predict increased risk for early breast cancer depending on the mixture that represents internal dose. It remains unclear whether individual differences in exposure, response to exposure, or both explain risk patterns observed.
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影响因子：
10.4
作者：
Berkowitz, Gertrud S;Obel, Josephine;Deych, Elena;Lapinski, Robert;Godbold, James;Liu, Zhisong;Landrigan, Philip J;Wolff, Mary S
通讯作者：
Wolff, Mary S
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通讯作者：
Loi, Sherene
影响因子：
10.4
作者：
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通讯作者：
Fenton SE
影响因子：
10.4
作者：
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通讯作者：
Makris SL
影响因子：
3.3
作者：
Cohn, Barbara A.
通讯作者：
Cohn, Barbara A.