Innate and adaptive immune interactions at the fetal-maternal interface in healthy human pregnancy and pre-eclampsia.
Innate and adaptive immune interactions at the fetal-maternal interface in healthy human pregnancy and pre-eclampsia.
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DOI：
10.3389/fimmu.2014.00125
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发表时间：
2014
影响因子：
7.3
通讯作者：
Nanan RK
中科院分区：
文献类型：
--
作者：
Hsu P;Nanan RK
母体对胎儿的免疫耐受对于健康的妊娠结局是必不可少的。这种免疫耐受在胎儿-母体界面--蜕膜、着床部位和胎盘形成中最为重要。事实上，许多证据表明，常见的妊娠相关疾病先兆子痫的免疫学起源。在先天免疫系统中，蜕膜NK细胞和抗原呈递细胞（包括树突细胞和巨噬细胞）占蜕膜白细胞群体的很大比例，并且被认为调节血管重塑和滋养层侵袭。另一方面，在适应性免疫系统中，Foxp3+调节性T细胞对于确保对半同种异体胎儿的免疫耐受至关重要。此外，另一群CD4 + HLA-G+抑制性T细胞也被鉴定为维持免疫耐受的潜在参与者。最近，研究开始揭示蜕膜内先天免疫系统和适应性免疫系统之间的潜在相互作用，这是维持健康妊娠所必需的。在这篇综述中，我们讨论了最近的进展，探索复杂的串扰之间的先天性和适应性免疫系统在人类怀孕。
Maternal immune tolerance of the fetus is indispensable for a healthy pregnancy outcome. Nowhere is this immune tolerance more important than at the fetal–maternal interface – the decidua, the site of implantation, and placentation. Indeed, many lines of evidence suggest an immunological origin to the common pregnancy-related disorder, pre-eclampsia. Within the innate immune system, decidual NK cells and antigen presenting cells (including dendritic cells and macrophages) make up a large proportion of the decidual leukocyte population, and are thought to modulate vascular remodeling and trophoblast invasion. On the other hand, within the adaptive immune system, Foxp3+ regulatory T cells are crucial for ensuring immune tolerance toward the semi-allogeneic fetus. Additionally, another population of CD4+HLA-G+ suppressor T cells has also been identified as a potential player in the maintenance of immune tolerance. More recently, studies are beginning to unravel the potential interactions between the innate and the adaptive immune system within the decidua, that are required to maintain a healthy pregnancy. In this review, we discuss the recent advances exploring the complex crosstalk between the innate and the adaptive immune system during human pregnancy.
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