Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy.

Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy.
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等离子体纳米探针:从化学传感到医学诊断和治疗。

DOI:
10.1039/c3nr03633b
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发表时间:
2013-11-07
期刊:
影响因子:
6.7
通讯作者:
Yuan H
Yuan H
中科院分区:
材料科学2区
文献类型:
--
作者:
Vo-Dinh T;Fales AM;Griffin GD;Khoury CG;Liu Y;Ngo H;Norton SJ;Register JK;Wang HN;Yuan H

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本文概述了本实验室等离子体活性纳米探针在化学传感、医学诊断和治疗方面的发展和应用。分子前哨纳米探针为检测DNA/RNA生物标记物提供了一种独特的工具,无论是在均相溶液中还是在医疗诊断的芯片平台上。表面增强拉曼散射(SERS)过程的光谱选择性和高灵敏度与纳米探针固有的分子特异性相结合的可能性提供了一种重要的多重诊断方式。金纳米星可以提供一个很好的多模式平台,将双光子发光与光热疗法相结合,将拉曼成像与光动力学疗法相结合。几个使用SERS和基于光子学的治疗的光学检测的例子被用来说明等离子体纳米探针在治疗方面的用处和潜力,它无缝地结合了诊断和治疗。
This article provides an overview of the development and applications of plasmonics-active nanoprobes in our laboratory for chemical sensing, medical diagnostics and therapy. Molecular Sentinel nanoprobes provide a unique tool for DNA/RNA biomarker detection both in a homogeneous solution or on a chip platform for medical diagnostics. The possibility of combining spectral selectivity and high sensitivity of the surface-enhanced Raman scattering (SERS) process with the inherent molecular specificity of nanoprobes provides an important multiplex diagnostic modality. Gold nanostars can provide an excellent multi-modality platform, combining two-photon luminescence with photothermal therapy as well as Raman imaging with photodynamic therapy. Several examples of optical detection using SERS and photonics-based treatments are presented to illustrate the usefulness and potential of the plasmonic nanoprobes for theranostics, which seamlessly combines diagnostics and therapy.
DOI: 10.1016/j.nano.2010.07.009
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