Protective Prevention Effects on the Association of Poverty With Brain Development.
Protective Prevention Effects on the Association of Poverty With Brain Development.
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DOI：
10.1001/jamapediatrics.2016.2988
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发表时间：
2017-01-01
期刊：
影响因子：
26.1
通讯作者：
Sweet, Lawrence H.
中科院分区：
文献类型：
--
作者：
Brody, Gene H.;Gray, Joshua C.;Yu, Tianyi;Barton, Allen W.;Beach, Steven R. H.;Galvan, Adrianna;MacKillop, James;Windle, Michael;Chen, Edith;Miller, Gregory E.;Sweet, Lawrence H.
这项研究提供了第一个数据表明，农村非洲裔美国人的参与，在儿童时期在11岁，在预防性干预，旨在加强支持性养育改善了贫困与海马和杏仁体体积在成年期在25岁。为了确定是否参与一个有效的预防计划，旨在加强支持性养育农村非洲裔美国儿童将改善生活在贫困和海马和杏仁核体积减少，这是明显的，在25岁之间的关联。在美国东南部的农村，非裔美国人的父母和他们11岁的孩子被随机分配到强大的非裔美国人家庭（SAAF）计划或控制条件。父母提供的数据用于计算子女11至13岁和16至18岁时的收入与需求比率。当孩子们25岁时，使用磁共振成像测量海马和杏仁核的体积。家庭贫穷是按收入与需求的比率来衡量的。年轻人的整个海马，齿状回和CA3海马子字段，和杏仁核体积进行了评估，使用磁共振成像。在11至18岁的贫困年龄段中，预测在对照条件下的年轻人中左齿状回和CA3海马子区域和左杏仁核体积减少，但在参与SAAF的人中则没有。研究表明，支持性的父母教育可以抵消儿童和青少年时期因贫困而对大脑发育造成的风险。在这项研究之前，尚不清楚这些发现是否反映了因果关系。在这项研究中，我们描述了如何参与一项随机对照试验，旨在提高支持性养育改善了贫困生活的年数与左齿状回和CA3海马子字段和左杏仁核体积的关联。这些研究结果是一致的因果作用，支持养育，并建议缩小社会差距的战略。
This study provides the first data showing that rural African Americans' participation, during childhood at age 11, in a preventive intervention designed to enhance supportive parenting ameliorates the association of poverty with hippocampal and amygdalar volumes during adulthood at age 25. To determine whether participation in an efficacious prevention program designed to enhance supportive parenting for rural African American children will ameliorate the association between living in poverty and reduced hippocampal and amygdalar volumes that are evident at age 25. In the rural southeastern United States, African American parents and their 11-year-old children were assigned randomly to the Strong African American Families (SAAF) program or to a control condition. Parents provided data used to calculate income-to-needs ratios when children were 11 to 13 and 16 to 18 years of age. When the children were 25 years of age, hippocampal and amygdalar volumes were measured using magnetic resonance imaging. Household poverty was measured by income-to-needs ratios. Young adults' whole hippocampal, dentate gyrus and CA3 hippocampal subfields, and amygdalar volumes were assessed using magnetic resonance imaging. Years lived in poverty across ages 11 to 18 years forecast diminished left dentate gyrus and CA3 hippocampal subfields and left amygdalar volumes among young adults in the control condition but not among those who participated in SAAF. Studies suggest that supportive parenting may offset risks to brain development posed by exposure to poverty during childhood and adolescence. Prior to this study, it was less clear whether these findings reflected a causal process. In this study, we described how participation in a randomized, controlled trial designed to enhance supportive parenting ameliorated the association of years lived in poverty with left dentate gyrus and CA3 hippocampal subfields and left amygdalar volumes. These findings are consistent with a causal role for supportive parenting and suggest a strategy for narrowing social disparities.
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影响因子：
11
作者：
Chen, E.;Miller, G. E.;Kobor, M. S.;Cole, S. W.
通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
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作者：
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影响因子：
16.2
作者：
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通讯作者：
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