Thorium and fetal neural tube defects: an epidemiological evidence from large case-control study.
Thorium and fetal neural tube defects: an epidemiological evidence from large case-control study.
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钍和胎儿神经管缺陷：来自大型病例对照研究的流行病学证据。
DOI：
10.1186/s41021-021-00227-w
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发表时间：
2021-11-25
期刊：
影响因子：
--
通讯作者：
Ren A
中科院分区：
文献类型：
--
作者：
Wang B;Pang Y;Zhang Y;Zhang L;Ye R;Yan L;Li Z;Ren A
钍在环境中普遍存在，其与出生缺陷的关系仍在讨论中。本研究旨在通过病例对照研究探讨孕产妇钍暴露与神经管缺陷（NTD）风险的关系，以及钍暴露与燃煤室内空气污染之间的关系。本研究于2003-2007年在中国山西和河北省的11家地方医疗保健医院进行。共有774名母亲被纳入作为参与者，他们分娩了263名NTD胎儿，其中包括123名无脑畸形，115名脊柱裂，18名脑膨出和7名其他NTD亚型（病例），以及511名无NTD的健康胎儿（对照）。收集她们的头发样本，尽可能接近枕后头皮，其中从怀孕前3个月到怀孕后3个月生长的头发被切断，以电感耦合等离子体质谱法测量钍浓度。我们发现总NTD病例的头发钍浓度为0.901（0.588-1.382）ng/g头发[中位数（四分位数间距）]，高于对照组的0.621（0.334-1.058）ng/g头发。三种相关NTD亚型的结果相似。母体头发钍浓度高于对照组中位数与总NTD风险增加相关，调整所有混杂因素后的调整比值比为1.80 [95%置信区间（CI），1.23-2.63）]。母亲发钍浓度与总NTDs及其两种亚型（无脑儿和脊柱裂）患病风险之间存在明显的剂量-反应关系。母亲发钍浓度与其暴露水平呈正相关。总体而言，我们的研究结果表明，母亲围产期钍暴露与NTDs的风险在中国北方。减少家庭烹饪活动中的煤炭使用量可能会降低母亲的钍暴露水平。在线版本包含补充材料，可通过10.1186/s41021-021-00227-w获得。
Thorium is ubiquitous in the environment and its relationship with birth defects is still under discussion. This study aimed to investigate the associations of maternal exposure to thorium with risk of neural tube defects (NTDs) by using a case–control study, as well as the relationship between thorium exposure and the indoor air pollution from coal combustion. This study was conducted in 11 local healthcare hospitals during 2003–2007 in Shanxi and Hebei provinces, China. A total of 774 mothers were included as participants who delivering 263 fetuses with NTDs including 123 with anencephaly, 115 with spina bifida, 18 with encephalocele, and 7 other NTD subtypes (cases), and 511 health fetuses without NTDs (controls). Their hair samples were collected as close as to the occipital posterior scalp, of which those grew from 3 months before to 3 months after conception was cut to measure the thorium concentration by inductively coupled plasma-mass spectrometry. We found a higher hair thorium concentration in the total NTD cases with 0.901 (0.588–1.382) ng/g hair [median (inter-quartile range)] than that in the controls with a value of 0.621 (0.334–1.058) ng/g hair. Similar results were found for the three concerned NTD subtypes. Maternal hair thorium concentration above its median of the controls was associated with an increased risk of the total NTDs with an adjusted odds ratio of 1.80 [95% confidence interval (CI), 1.23–2.63)] by adjusting for all confounders. There was obvious dose-response relationship between maternal hair thorium concentration and the risk of total NTDs, as well as their two subtypes (i.e. anencephaly and spina bifida). Maternal hair thorium concentration was positive associated with their exposure level to indoor air pollution from coal combustion during cooking. Overall, our findings revealed that maternal periconceptional thorium exposure was associated with the risk of NTDs in North China. Reducing the coal usage in the household cooking activities may decrease maternal thorium exposure level. The online version contains supplementary material available at 10.1186/s41021-021-00227-w.
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影响因子：
5.2
作者：
Li, Zhiwen;Zhang, Le;Ren, Aiguo
通讯作者：
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影响因子：
2.3
作者：
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DOI：
10.1016/j.xinn.2021.100172
发表时间：
2021-11-28
期刊：
Innovation (Cambridge (Mass.))
影响因子：
--
作者：
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通讯作者：
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影响因子：
158.5
作者：
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通讯作者：
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