Long Covid: where we stand and challenges ahead.
Long Covid: where we stand and challenges ahead.
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DOI：
10.1038/s41418-022-01052-6
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发表时间：
2022-10
影响因子：
12.4
通讯作者：
Bussolati, Giovanni
中科院分区：
文献类型：
--
作者：
Mantovani, Alberto;Morrone, Maria Concetta;Patrono, Carlo;Santoro, M. Gabriella;Schiaffino, Stefano;Remuzzi, Giuseppe;Bussolati, Giovanni
Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and colloquially as Long Covid, has been defined as a constellation of signs and symptoms which persist for weeks or months after the initial SARS-CoV-2 infection. PASC affects a wide range of diverse organs and systems, with manifestations involving lungs, brain, the cardiovascular system and other organs such as kidney and the neuromuscular system. The pathogenesis of PASC is complex and multifactorial. Evidence suggests that seeding and persistence of SARS-CoV-2 in different organs, reactivation, and response to unrelated viruses such as EBV, autoimmunity, and uncontrolled inflammation are major drivers of PASC. The relative importance of pathogenetic pathways may differ in different tissue and organ contexts. Evidence suggests that vaccination, in addition to protecting against disease, reduces PASC after breakthrough infection although its actual impact remains to be defined. PASC represents a formidable challenge for health care systems and dissecting pathogenetic mechanisms may pave the way to targeted preventive and therapeutic approaches.
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影响因子：
4.6
作者：
Aranyó J;Bazan V;Lladós G;Dominguez MJ;Bisbal F;Massanella M;Sarrias A;Adeliño R;Riverola A;Paredes R;Clotet B;Bayés-Genís A;Mateu L;Villuendas R
通讯作者：
Villuendas R
DOI：
10.1126/science.abj7965
发表时间：
2021-11-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Casanova JL;Abel L
通讯作者：
Abel L
DOI：
10.2967/jnumed.121.262128
发表时间：
2021-07-01
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Blazhenets G;Schroeter N;Bormann T;Thurow J;Wagner D;Frings L;Weiller C;Meyer PT;Dressing A;Hosp JA
通讯作者：
Hosp JA
影响因子：
4.1
作者：
Cares-Marambio K;Montenegro-Jiménez Y;Torres-Castro R;Vera-Uribe R;Torralba Y;Alsina-Restoy X;Vasconcello-Castillo L;Vilaró J
通讯作者：
Vilaró J
影响因子：
9.3
作者：
Bucciarelli V;Nasi M;Bianco F;Seferovic J;Ivkovic V;Gallina S;Mattioli AV
通讯作者：
Mattioli AV