Altered functional connectivity of the default mode network in diffuse gliomas measured with pseudo-resting state fMRI.
Altered functional connectivity of the default mode network in diffuse gliomas measured with pseudo-resting state fMRI.
复制标题
DOI：
10.1007/s11060-013-1304-2
复制
发表时间：
2014-01
影响因子：
3.9
通讯作者：
Ellingson BM
中科院分区：
文献类型：
--
作者：
Harris RJ;Bookheimer SY;Cloughesy TF;Kim HJ;Pope WB;Lai A;Nghiemphu PL;Liau LM;Ellingson BM
本研究的目的是探讨脑肿瘤是否破坏默认模式网络（DMN）的完整性，DMN是一个特征良好的静息状态功能磁共振成像网络。我们评估了胶质瘤患者的肿瘤分级、体积、术后/临床状态或位置是否降低了DMN内的功能连接。基于任务的fMRI数据来自68例弥漫性胶质瘤患者和12名健康志愿者。伪静息状态fMRI数据计算基于任务的fMRI数据使用标准技术。对数据进行预处理，并使用单变量和多变量线性模型在WHO分级、肿瘤体积、手术状态（新发与复发肿瘤）、年龄和KPS之间比较DMN完整性。WHO分级是DMN完整性最重要的预测因子（P = 0.004），而T2高信号病变体积不是预测因子（P = 0.154）。高级别（WHO III-IV）患者的DMN完整性低于低级别（WHO II）患者（P = 0.020）。与额叶肿瘤相比，左顶叶肿瘤的DMN受损更严重，而网络节点内外的肿瘤没有显著差异。结果表明，较高的肿瘤等级沿着既往手术和/或治疗导致原发性胶质瘤患者DMN功能连接的最大程度降低，并且肿瘤位置对连接有影响。
The purpose of the current study was to explore whether brain tumors disrupt the integrity of the default mode network (DMN), a well-characterized resting-state fMRI network. We evaluated whether tumor grade, volume, post-surgical/clinical status, or location decreased the functional connectivity within the DMN in patients with gliomas. Task-based fMRI data was obtained from 68 diffuse glioma patients and 12 healthy volunteers. Pseudo-resting state fMRI data was calculated from task-based fMRI data using standard techniques. Data was preprocessed and DMN integrity was compared across WHO grade, tumor volume surgical status (new vs. recurrent tumors), age, and KPS using univariate and multivariate linear models. WHO grade was the most significant predictor of DMN integrity (P = 0.004), whereas T2 hyperintense lesion volume was not a predictor (P = 0.154). DMN integrity was lower in high-grade (WHO III–IV) compared with low-grade (WHO II) patients (P = 0.020). Tumors in the left parietal lobe showed a more impaired DMN compared with tumors in the frontal lobe, while tumors within and outside the network nodes did not differ significantly. Results suggest higher tumor grade along with prior surgery and/or treatment cause the largest reduction in DMN functional connectivity in patients with primary gliomas, and that tumor location has an impact on connectivity.
登录
查看更多内容
使用功能性磁共振成像成像的神经元活性中的自发波动在脑肿瘤患者中的术前感官图：初始体验。
影响因子：
4.8
作者：
Zhang D;Johnston JM;Fox MD;Leuthardt EC;Grubb RL;Chicoine MR;Smyth MD;Snyder AZ;Raichle ME;Shimony JS
通讯作者：
Shimony JS
影响因子：
3.2
作者：
Persson, Jonas;Lustig, Cindy;Reuter-Lorenz, Patricia A.
通讯作者：
Reuter-Lorenz, Patricia A.
DOI：
10.1093/brain/aws041
发表时间：
2012-04
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Otten ML;Mikell CB;Youngerman BE;Liston C;Sisti MB;Bruce JN;Small SA;McKhann GM 2nd
通讯作者：
McKhann GM 2nd
影响因子：
3.7
作者：
Waltz JA;Kasanova Z;Ross TJ;Salmeron BJ;McMahon RP;Gold JM;Stein EA
通讯作者：
Stein EA
影响因子：
12.7
作者：
Claes A;Idema AJ;Wesseling P
通讯作者：
Wesseling P