Norovirus: Facts and Reflections from Past, Present, and Future

Norovirus: Facts and Reflections from Past, Present, and Future
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DOI:
10.3390/v13122399
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发表时间:
2021-11-30
期刊:
Viruses
影响因子:
--
通讯作者:
O’Ryan M
O’Ryan M
中科院分区:
其他
文献类型:
--
作者:
Lucero Y;Matson DO;Ashkenazi S;George S;O’Ryan M

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诺如病毒是目前世界上大多数国家急性胃肠炎(AGEs)的主要病毒病因。在Kapikian及其同事发现“诺瓦克病毒”近50年后,科学和医学界继续产生关于诺如病毒感染的完整生物学和疾病谱的新知识。然而,由于有效复制和传播病毒的严重限制,对几个领域仍然没有完全了解。在这里,我们提出了一个叙述性的历史观点,并总结了我们目前的知识,包括对广泛的医学界当前兴趣点的见解和思考,包括临床和分子流行病学,病毒-宿主-微生物群相互作用,抗病毒药物和疫苗原型。我们亦反思COVID-19疫情对诺如病毒感染及疾病的现时及未来影响。
Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral–host–microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease.
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