Biomimetic Hydrogels to Promote Wound Healing.
Biomimetic Hydrogels to Promote Wound Healing.
复制标题
促进伤口愈合的仿生水凝胶。
DOI：
10.3389/fbioe.2021.718377
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发表时间：
2021
影响因子：
5.7
通讯作者：
Hanjaya-Putra D
中科院分区：
文献类型：
--
作者：
Fan F;Saha S;Hanjaya-Putra D
创伤愈合是一种常见的生理过程，其由在组织损伤开始后发生的一系列分子和细胞事件组成，以重建身体与外部环境之间的屏障。水凝胶的固有性质允许受损组织通过支持水合环境来愈合，这在伤口管理中已被长期探索以帮助自溶清创。然而，慢性不愈合伤口需要额外的治疗功能，可以通过掺入生物分子和支持细胞来实现，以促进更快和更好的愈合结果。近几十年来，已经开发和修改了许多水凝胶，以匹配伤口愈合不同阶段的时间尺度。本文将讨论各种类型的水凝胶对伤口病理生理的影响，以及用于伤口愈合的水凝胶的理想特性，交联机制，制造技术和水凝胶工程的设计考虑。最后，讨论了采用水凝胶促进伤口愈合的几个挑战和未来的前景。
Wound healing is a common physiological process which consists of a sequence of molecular and cellular events that occur following the onset of a tissue lesion in order to reconstitute barrier between body and external environment. The inherent properties of hydrogels allow the damaged tissue to heal by supporting a hydrated environment which has long been explored in wound management to aid in autolytic debridement. However, chronic non-healing wounds require added therapeutic features that can be achieved by incorporation of biomolecules and supporting cells to promote faster and better healing outcomes. In recent decades, numerous hydrogels have been developed and modified to match the time scale for distinct stages of wound healing. This review will discuss the effects of various types of hydrogels on wound pathophysiology, as well as the ideal characteristics of hydrogels for wound healing, crosslinking mechanism, fabrication techniques and design considerations of hydrogel engineering. Finally, several challenges related to adopting hydrogels to promote wound healing and future perspectives are discussed.
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影响因子：
--
作者：
Ashoori Y;Mohkam M;Heidari R;Abootalebi SN;Mousavi SM;Hashemi SA;Golkar N;Gholami A
通讯作者：
Gholami A
影响因子：
5.4
作者：
Amato G;Grimaudo MA;Alvarez-Lorenzo C;Concheiro A;Carbone C;Bonaccorso A;Puglisi G;Musumeci T
通讯作者：
Musumeci T
DOI：
10.4149/bll_2018_072
发表时间：
2018-01-01
影响因子：
1.5
作者：
Babavalian, H.;Tebyanian, H.;Shakeri, F.
通讯作者：
Shakeri, F.
影响因子：
4.6
作者：
Bahadoran, Maedeh;Shamloo, Amir;Nokoorani, Yeganeh Dorri
通讯作者：
Nokoorani, Yeganeh Dorri
仿生多功能混合水凝胶促进伤口愈合
影响因子：
19
作者：
Chen, Guopu;Yu, Yunru;Zhao, Yuanjin
通讯作者：
Zhao, Yuanjin