Zein-based nanoparticles: Preparation, characterization, and pharmaceutical application.
Zein-based nanoparticles: Preparation, characterization, and pharmaceutical application.
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DOI：
10.3389/fphar.2023.1120251
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发表时间：
2023
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
玉米蛋白作为植物中的天然GRAS蛋白之一，具有可再生、无毒、生物相容性和可生物降解性。在过去的十年中，许多研究工作致力于玉米蛋白基生物材料的多种工业应用。结合本课题组的研究经验，对玉米醇溶蛋白纳米粒子的制备方法、表征及药物应用进行了综述。通过化学交联、去溶剂化、分散和微混合策略制备了具有不同颗粒纳米结构的玉米醇溶蛋白纳米颗粒。玉米醇溶蛋白纳米颗粒的制药应用主要集中在药物递送方面。玉米醇溶蛋白纳米粒可以提高药物稳定性、增加口服生物利用度、控制药物释放、增强药物靶向性，从而有效提高药效。需要通过质量设计的方法分析制备方法、颗粒纳米结构和药物性质之间的关系，进一步促进玉米醇溶蛋白纳米粒的放大生产和临床应用。
Zein, as one of the natural and GRAS proteins in plant, is renewable, nontoxic, biocompatible and biodegradable. Over the past decade, many research efforts have been devoted to zein-based biomaterials for several industrial applications. Combining with research experiences in our research group, the preparation methods, characterizations and pharmaceutical applications of zein-based nanoparticles were summarized in this review. Zein NPs with different particle nanostructures have been prepared by chemical crosslinking, desolvating, dispersing and micromixing strategies. The pharmaceutical applications of zein NPs are mainly focus on the drug delivery. Zein NPs can improve the drug stability, increase the oral bioavailability, control the drug release and enhance the drug targeting, thereby improving the pharmaceutical effect effectively. More efforts are required to analyze the relationship among preparation methods, particle nanostructures and pharmaceutical properties in virtue of quality by design approach, and further promote the scale-up production and clinical application of zein NPs.
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