The influence of side group modification in polyphosphazenes on hydrolysis and cell adhesion of blends with PLGA.
The influence of side group modification in polyphosphazenes on hydrolysis and cell adhesion of blends with PLGA.
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DOI：
10.1016/j.biomaterials.2009.02.049
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发表时间：
2009-06
期刊：
影响因子：
14
通讯作者：
Allcock, Harry R.
中科院分区：
文献类型：
--
作者：
Krogman, Nicholas R.;Weikel, Arlin L.;Kristhart, Katherine A.;Nukavarapu, Syarn P.;Deng, Meng;Nair, Lakshmi S.;Laurencin, Cato T.;Allcock, Harry R.
以三(羟甲基)氨基甲烷(THAM)为侧基，甘氨酸乙酯和丙氨酸乙酯为共取代基合成了聚磷腈。THAM侧基通过氨基连接到聚磷腈骨架上。利用每个THAM侧基上的三个侧羟基与聚乙醇酸-乳酸(PLGA)进行氢键作用。用THAM和甘氨酸乙酯或丙氨酸乙酯共取代聚磷腈，以避免单取代基THAM取代的聚磷腈的不溶性。将聚[(三羟甲基氨基甲烷)(乙基甘氨酸基)磷腈]和聚[(三羟甲基氨基甲烷)(乙基丙氨酸基)磷腈](侧基比例为1：1)分别与PLGA(50：50)或PLGA(85：15)共混。DSC分析表明，无论共混物中聚磷腈的详细分子结构或PLGA的组成如何，共混物的形成都是相容的。对聚磷腈/PLGA(50：50)共混物的水解性研究表明，PLGA组分的水解速度比聚磷腈快。原代成骨细胞研究显示，在14天内，细胞与聚合物混合物的粘附性良好，但随后由于两种聚合物以不同的速度侵蚀而增加的表面粗糙度，细胞扩散有限。
Polyphosphazenes have been synthesized with tris(hydroxymethyl)amino methane (THAM) side groups and with co-substituents glycine ethyl ester and alanine ethyl ester. The THAM side group was linked to the polyphosphazene backbone via the amino function. The three pendent hydroxyl functions on each THAM side group were utilized for hydrogen bonding association with poly(glycolic-lactic acid) (PLGA). Co-substitution of the polyphosphazene with both THAM and glycine or alanine ethyl esters was employed to avoid the insolubility of the single-substituent THAM -substituted polyphosphazenes. Both poly[(tris(hydroxymethyl)aminomethane)(ethyl glycinato)phosphazene] and poly[(tris(hydroxymethyl)aminomethane)(ethyl alanato)phosphazene] (1:1 ratio of side groups) were blended with PLGA (50:50) or PLGA (85:15). DSC analysis indicated miscible blend formation, irrespective of the detailed molecular structure of the polyphosphazene or the composition of PLGA in the blend. Hydrolysis studies of the polyphosphazene:PLGA (50:50) blends indicated that the PLGA component hydrolyzed more rapidly than the polyphosphazene. Primary osteoblast cell studies showed good cell adhesion to the polymer blends during 14 days, but subsequent limited cell spreading due to increased surface roughness as the two polymers eroded at different rates.
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影响因子：
3
作者：
Alexis, Frank;Venkatraman, Subbu;Gan, Leong-Huat
通讯作者：
Gan, Leong-Huat
DOI：
10.1007/s10856-006-0185-8
发表时间：
2006-10-01
影响因子：
3.7
作者：
Andrade, Miguel G. S.;Weissman, Ruben;Reis, Silvia R. A.
通讯作者：
Reis, Silvia R. A.
DOI：
10.1007/s10904-006-9096-x
发表时间：
2006-12-01
影响因子：
4
作者：
El-Amin, Saadiq F.;Kwon, Michael S.;Laurencin, Cato T.
通讯作者：
Laurencin, Cato T.
影响因子：
3.8
作者：
Jabbarzadeh, Ehsan;Jiang, Tao;Laurencin, Cato T.
通讯作者：
Laurencin, Cato T.
影响因子：
5.5
作者：
ALLCOCK, HR;PUCHER, SR;SCOPELIANOS, AG
通讯作者：
SCOPELIANOS, AG