A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish.
A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish.
复制标题
来自转基因Camelina sativa的营养增强油有效地取代了鱼油，作为鱼油的来源。
DOI：
10.1038/srep08104
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发表时间：
2015-01-29
影响因子：
4.6
通讯作者：
Tocher DR
中科院分区：
文献类型：
--
作者：
Betancor MB;Sprague M;Usher S;Sayanova O;Campbell PJ;Napier JA;Tocher DR
对于人类来说，建议每天摄入高达500毫克的omega-3 （n-3）长链多不饱和脂肪酸（LC-PUFA），相当于70亿人口每年需要125万公吨。全球n-3 LC-PUFA的年供应量无法满足这一需求水平，因此存在较大的供需缺口。水产养殖越来越多地提供n-3 LC-PUFA的膳食来源——鱼类和海产品，但在饲料中使用鱼油来提供n-3 LC-PUFA是不可持续的。因此，需要新的n-3 LC-PUFA来源来满足水产养殖和人类直接消费的需求。一种方法是对油籽作物进行代谢工程，在种子中合成n- 3lc - pufa。利用表达藻类基因的转基因亚麻荠生产了一种含n-3 LC-PUFA的油，用于替代三文鱼饲料中的鱼油。该油对鱼的生产性能、代谢反应和鱼片的营养品质均无不良影响。
For humans a daily intake of up to 500 mg omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) is recommended, amounting to an annual requirement of 1.25 million metric tonnes (mt) for a population of 7 billion people. The annual global supply of n-3 LC-PUFA cannot meet this level of requirement and so there is a large gap between supply and demand. The dietary source of n-3 LC-PUFA, fish and seafood, is increasingly provided by aquaculture but using fish oil in feeds to supply n-3 LC-PUFA is unsustainable. Therefore, new sources of n-3 LC-PUFA are required to supply the demand from aquaculture and direct human consumption. One approach is metabolically engineering oilseed crops to synthesize n-3 LC-PUFA in seeds. Transgenic Camelina sativa expressing algal genes was used to produce an oil containing n-3 LC-PUFA to replace fish oil in salmon feeds. The oil had no detrimental effects on fish performance, metabolic responses or the nutritional quality of the fillets of the farmed fish.
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