The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis.

The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis.
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DOI:
10.1186/s13756-021-00943-6
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发表时间:
2021-05-01
影响因子:
5.5
通讯作者:
Dadashi M
Dadashi M
中科院分区:
医学2区
文献类型:
--
作者:
Hajikhani B;Goudarzi M;Kakavandi S;Amini S;Zamani S;van Belkum A;Goudarzi H;Dadashi M

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金黄色葡萄球菌(S.金黄色葡萄球菌)是引起医院和社区获得性感染的最常见病原体之一,具有高发病率和死亡率。夫西地酸已越来越多地用于治疗由甲氧西林敏感的S.金黄色葡萄球菌(MSSA)和耐甲氧西林葡萄球菌。金黄色葡萄球菌(MRSA)。本研究的目的是确定耐夫西地酸MRSA(FRMRSA)、耐夫西地酸MSSA(FRMSSA)和总耐夫西地酸S。金黄色葡萄球菌(FRSA)的研究。检索了几个国际数据库,包括Medline、Embase和Web of Sciences(2000-2020年),以识别涉及FRSA、FRMRSA和FRMSSA患病率的研究。使用STATA(版本14)软件解释数据。在从数据库中识别出的1446条记录中,215项研究符合检出FRSA(208项研究)、FRMRSA(143项研究)和FRMSSA(71项研究)的合格性标准。分析表明,FRSA、FRMRSA和FRMSSA的全球患病率分别为0.5%、2.6%和6.7%。该荟萃分析描述了FRSA、FRMSSA和FRMRSA的发病率增加。这些结果表明,需要谨慎处方夫西地酸,以停止或减少夫西地酸耐药的发生率,以及开发监测夫西地酸使用效果的策略。在线版本包含补充材料,可登录10.1186/s13756-021-00943-6获取。
Staphylococcus aureus (S. aureus) is one of the most common pathogens causing nosocomial and community-acquired infections with high morbidity and mortality rates. Fusidic acid has been increasingly used for the treatment of infections due to methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The present study aimed to determine the precise prevalence of fusidic acid resistant MRSA (FRMRSA), fusidic acid resistant MSSA (FRMSSA), and total fusidic acid resistant S. aureus (FRSA) on a global scale. Several international databases including Medline, Embase, and the Web of Sciences were searched (2000–2020) to discern studies addressing the prevalence of FRSA, FRMRSA, and FRMSSA. STATA (version14) software was used to interpret the data. Of the 1446 records identified from the databases, 215 studies fulfilled the eligibility criteria for the detection of FRSA (208 studies), FRMRSA (143 studies), and FRMSSA (71 studies). The analyses manifested that the global prevalence of FRSA, FRMRSA, and FRMSSA was 0.5%, 2.6% and 6.7%, respectively. This meta-analysis describes an increasing incidence of FRSA, FRMSSA, and FRMRSA. These results indicate the need for prudent prescription of fusidic acid to stop or diminish the incidence of fusidic acid resistance as well as the development of strategies for monitoring the efficacy of fusidic acid use. The online version contains supplementary material available at 10.1186/s13756-021-00943-6.
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发表时间: 2017-09-01
影响因子: 4.6
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