Size, weight and position: ion mobility spectrometry and imaging MS combined.

Size, weight and position: ion mobility spectrometry and imaging MS combined.
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DOI:
10.1007/s00216-010-4644-1
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发表时间:
2011-03
影响因子:
4.3
通讯作者:
Heeren, Ron M. A.
Heeren, Ron M. A.
中科院分区:
化学2区
文献类型:
--
作者:
Kiss, Andras;Heeren, Ron M. A.

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大小、重量和位置是描述生物系统中分子的三个最重要的参数。离子迁移谱能够根据分子的大小或形状分离分子,而成像质谱是测量分子量和分子空间分布的有效工具。这两个领域的最新发展使这两种技术得以结合。因此,基于离子迁移率的成像质谱作为(生物)分析工具越来越受欢迎,其能够同时确定生物表面上的几个分子的大小、重量和位置。本文综述了离子迁移率成像质谱的发展,并提供了其在生物表面分析研究中的应用实例。
Size, weight and position are three of the most important parameters that describe a molecule in a biological system. Ion mobility spectrometry is capable of separating molecules on the basis of their size or shape, whereas imaging mass spectrometry is an effective tool to measure the molecular weight and spatial distribution of molecules. Recent developments in both fields enabled the combination of the two technologies. As a result, ion-mobility-based imaging mass spectrometry is gaining more and more popularity as a (bio-)analytical tool enabling the determination of the size, weight and position of several molecules simultaneously on biological surfaces. This paper reviews the evolution of ion-mobility-based imaging mass spectrometry and provides examples of its application in analytical studies of biological surfaces.
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