Influences of temporal lobe epilepsy and temporal lobe resection on olfaction.
Influences of temporal lobe epilepsy and temporal lobe resection on olfaction.
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DOI：
10.1007/s00415-018-8891-y
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发表时间：
2018-07
影响因子：
6
通讯作者：
Detre JA
中科院分区：
文献类型：
--
作者：
Doty RL;Tourbier I;Neff JK;Silas J;Turetsky B;Moberg P;Kim T;Pluta J;French J;Sharan AD;Sperling MJ;Mirza N;Risser A;Baltuch G;Detre JA
虽然颞叶癫痫（TLE）和颞叶切除（TLR）会影响嗅觉大脑结构，但它们对嗅觉的影响仍然是谜。我们试图更明确地评估TLE和TLR的影响，使用了三个经过验证的嗅觉测试，以及这些测试与许多颞叶大脑结构的体积的关联。对71例TLE患者和71例年龄和性别匹配的对照组进行宾夕法尼亚大学气味识别测试和气味检测阈值测试；69例TLE患者和对照组接受气味识别/记忆测试。57例患者和57例对照组在TLR前后进行气味识别和阈值测试；27名患者和27名对照组进行了类似的气味检测/辨别测试。使用方差分析比较得分，并与术前和术后目标脑结构的体积相关。TLE与所有测试指标的双侧缺陷有关。TLR进一步降低了切除侧同侧的功能。TLE受试者的焦点侧海马和其他结构更小。尽管在大多数测量的脑结构中，术后体积明显减少，但在某些情况下，对侧体积适度增加。术前和术后嗅觉测试分数与结构体积之间没有明显的相关性。总之，我们证明嗅觉功能障碍显然是TLE和TLR的关键因素，影响气味识别、检测和辨别/记忆。我们关于术后对侧脑结构体积显著增加的新发现是否反映了可塑性和代偿过程，需要进一步研究。
Although temporal lobe epilepsy (TLE) and resection (TLR) impact olfactory eloquent brain structures, their influences on olfaction remain enigmatic. We sought to more definitively assess the influences of TLE and TLR using three well-validated olfactory tests and the tests’ associations with the volume of numerous temporal lobe brain structures. The University of Pennsylvania Smell Identification Test and an odor detection threshold test were administered to 71 TLE patients and 71 age- and sex-matched controls; 69 TLE patients and controls received an odor discrimination/memory test. Fifty-seven patients and 57 controls were tested on odor identification and threshold before and after TLR; 27 patients and 27 controls were similarly tested for odor detection/discrimination. Scores were compared using analysis of variance and correlated with pre- and post-operative volumes of the target brain structures. TLE was associated with bilateral deficits in all test measures. TLR further decreased function on the side ipsilateral to resection. The hippocampus and other structures were smaller on the focus side of the TLE subjects. Although post-operative volumetric decreases were evident in most measured brain structures, modest contralateral volumetric increases were observed in some cases. No meaningful correlations were evident pre- or post-operatively between the olfactory test scores and the structural volumes. In conclusion, we demonstrate that smell dysfunction is clearly a key element of both TLE and TLR, impacting odor identification, detection, and discrimination/memory. Whether our novel finding of significant post-operative increases in the volume of brain structures contralateral to the resection side reflects plasticity and compensatory processes requires further study.
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影响因子：
3.5
作者：
Doty, RL;McKeown, DA;Shaman, P
通讯作者：
Shaman, P
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M
影响因子：
14.5
作者：
EICHENBAUM, H;MORTON, TH;CORKIN, S
通讯作者：
CORKIN, S
影响因子：
6
作者：
Hummel, Thomas;Henkel, Sophia;Haehner, Antje
通讯作者：
Haehner, Antje
影响因子：
5.7
作者：
Ciumas, Carolina;Lindstroem, Per;Savic, Ivanka
通讯作者：
Savic, Ivanka