Role of breast regression protein-39/YKL-40 in asthma and allergic responses.
Role of breast regression protein-39/YKL-40 in asthma and allergic responses.
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DOI：
10.4168/aair.2010.2.1.20
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Elias JA
中科院分区：
文献类型：
--
作者：
Lee CG;Elias JA
BRP-39及其人同源物YKL-40被认为是哺乳动物中几丁质酶样蛋白（CLP）的原型。在许多以炎症、组织重塑和异常细胞生长为特征的疾病中已经注意到YKL-40蛋白和/或mRNA水平升高。哮喘是一种以气道高反应性和气道重塑为特征的炎症性疾病。最近，BRP-39/YKL-40在哮喘发病机制中的新调节作用已在人体研究和过敏性动物模型中得到证实。YKL-40水平在哮喘患者的循环和肺中增加，其中它们与疾病严重程度相关，并且CHI 3L 1多态性与血清YKL-40水平、哮喘和异常肺功能相关。使用BRP-39无效突变小鼠的动物研究表明，BRP-39是最佳过敏原致敏和Th 2炎症所需的。这些研究表明BRP-39作为生物标志物以及哮喘和其他过敏性疾病的治疗靶点的潜在用途。在这里，我们提出了一个几丁质/几丁质酶生物学的概述，并总结了最近的发现BRP-39在哮喘和过敏反应的发病机制中的作用。
BRP-39 and its human homolog YKL-40 have been regarded as a prototype of chitinase-like proteins (CLP) in mammals. Exaggerated levels of YKL-40 protein and/or mRNA have been noted in a number of diseases characterized by inflammation, tissue remodeling, and aberrant cell growth. Asthma is an inflammatory disease characterized by airway hyperresponsiveness and airway remodeling. Recently, the novel regulatory role of BRP-39/YKL-40 in the pathogenesis of asthma has been demonstrated both in human studies and allergic animal models. The levels of YKL-40 are increased in the circulation and lungs from asthmatics where they correlate with disease severity, and CHI3L1 polymorphisms correlate with serum YKL-40 levels, asthma and abnormal lung function. Animal studies using BRP-39 null mutant mice demonstrated that BRP-39 was required for optimal allergen sensitization and Th2 inflammation. These studies suggest the potential use of BRP-39 as a biomarker as well as a therapeutic target for asthma and other allergic diseases. Here, we present an overview of chitin/chitinase biology and summarize recent findings on the role of BRP-39 in the pathogenesis of asthma and allergic responses.
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影响因子：
4.4
作者：
Da Silva, Carla A.;Chalouni, Cecile;Elias, Jack A.
通讯作者：
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作者：
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作者：
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