Urinary concentrations of phenols, parabens, and triclocarban in relation to uterine leiomyomata incidence and growth.
Urinary concentrations of phenols, parabens, and triclocarban in relation to uterine leiomyomata incidence and growth.
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DOI：
10.1016/j.fertnstert.2021.07.003
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发表时间：
2021-12
影响因子：
6.7
通讯作者：
Wise LA
中科院分区：
文献类型：
--
作者：
Wesselink AK;Weuve J;Fruh V;Bethea TN;Claus Henn B;Harmon QE;Hauser R;Williams PL;Calafat AM;McClean M;Baird DD;Wise LA
研究苯酚、对羟基苯甲酸酯和三氯卡班的尿浓度与子宫平滑肌瘤（UL;肌瘤）的发生率和生长的关系。病例队列研究，嵌套在环境，生活方式和子宫肌瘤研究（SELF）中，这是一项前瞻性队列研究。基线时和每20个月一次的门诊访视，持续60个月。754名年龄在23-35岁的黑人妇女居住在底特律，密歇根州地区（在2010-2012年期间登记）。没有。在每次研究访视时，女性接受经阴道超声测量UL发病率和生长情况，并提供尿液样本，其中我们定量了7种酚类、4种对羟基苯甲酸酯和三氯卡班的浓度。我们使用考克斯比例风险回归来估计风险比（HR）和95%置信区间（CI），以表征60个月随访期间尿液生物标志物浓度与UL发生率的关系。在多个时间点检测和测量的UL子集中，我们使用线性回归来评估生物标志物浓度和UL生长之间的关联。尿生物标志物浓度通常与UL发病率呈负相关，但相关性较弱且非单调。例如，双酚A、双酚S和对羟基苯甲酸甲酯的HR分别为0.77（95% CI：0.46，1.27）、0.72（95% CI：0.40，1.28）和0.76（95% CI：0.43，1.33）。生物标志物浓度与UL生长没有强相关性。在这项对育龄黑人妇女的研究中，尿酚、对羟基苯甲酸酯和三氯卡班生物标志物与UL发病率和生长既不强烈也不一致。在这项前瞻性、基于超声的育龄黑人妇女病例队列研究中，苯酚、对羟基苯甲酸酯和三氯卡班的尿浓度与子宫平滑肌瘤的发生率或生长无关。
To examine the association of urinary concentrations of phenols, parabens, and triclocarban with incidence and growth of uterine leiomyomata (UL; fibroids). Case-cohort study, nested within the Study of Environment, Lifestyle and Fibroids (SELF), a prospective cohort study. Clinic visits at baseline and every 20 months for 60 months. 754 Black women aged 23–35 years residing in the Detroit, Michigan area (enrolled during 2010–2012). None. At each study visit, women underwent transvaginal ultrasound for measurement of UL incidence and growth and provided urine specimens in which we quantified concentrations of 7 phenols, 4 parabens, and triclocarban. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) characterizing the relation of urinary biomarker concentrations with UL incidence during 60 months of follow-up. In a subset of UL detected and measured at multiple time points, we used linear regression to assess associations between biomarker concentrations and UL growth. Urinary biomarker concentrations were generally inversely associated with UL incidence, but associations were weak and non-monotonic. For example, HRs comparing concentrations ≥90th with <50th percentile were 0.77 (95% CI: 0.46, 1.27) for bisphenol A, 0.72 (95% CI: 0.40, 1.28) for bisphenol S and 0.76 (95% CI: 0.43, 1.33) for methylparaben. Biomarker concentrations were not strongly associated with UL growth. In this study of reproductive-aged Black women, urinary phenols, parabens, and triclocarban biomarkers were neither strongly nor consistently associated with UL incidence and growth. In this prospective, ultrasound-based case-cohort study of reproductive-aged Black women, urinary concentrations of phenols, parabens, and triclocarban were not appreciably associated with incidence or growth of uterine leiomyomata.
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影响因子：
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