Complete Blood Count Reference Intervals and Patterns of Changes Across Pediatric, Adult, and Geriatric Ages in Korea.
Complete Blood Count Reference Intervals and Patterns of Changes Across Pediatric, Adult, and Geriatric Ages in Korea.
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DOI：
10.3343/alm.2018.38.6.503
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发表时间：
2018-11
影响因子：
4.9
通讯作者：
Cho HI
中科院分区：
文献类型：
--
作者：
Nah EH;Kim S;Cho S;Cho HI
对健康参考人群进行抽样，以生成全血细胞计数（CBC）参数的参考区间（RIs），这在儿童和老年人群中并不常见。我们利用二手数据建立了儿童、成人和老年年龄CBC参数的年龄和性别特异性RIs，评估CBC参数的变化模式。参考人群包括804,623名健康体检者（3-17岁66,611名；18-59岁564,280名；60-99岁173,732名），经离群检验排除22,766名体检者。对781857名体检者的CBC参数（红细胞、白细胞和血小板参数）进行了研究。我们确定了统计上显著的年龄和性别划分，并根据CLSI C28-A3指南计算RIs。红细胞参数在成年前随年龄增长而增加，男性随年龄增长而下降，但在青春期前增加，女性随年龄增长而下降。白细胞和血小板计数在儿童早期最高，随着年龄的增长而下降。注意到各年龄组的性别差异：成年期男性白细胞计数高于女性，但从青春期开始，女性血小板计数高于男性（P<0.001）。中性粒细胞计数在儿童早期最低，随着年龄的增长而增加。淋巴细胞计数在儿童早期达到峰值后，随着年龄的增长而下降。嗜酸性粒细胞计数在儿童期最高，且男性高于女性。男性单核细胞计数高于女性（P<0.001）。我们为CBC参数提供了全面的年龄和性别特异性RIs，这些参数显示出年龄和性别的动态变化。
Sampling a healthy reference population to generate reference intervals (RIs) for complete blood count (CBC) parameters is not common for pediatric and geriatric ages. We established age- and sex-specific RIs for CBC parameters across pediatric, adult, and geriatric ages using secondary data, evaluating patterns of changes in CBC parameters. The reference population comprised 804,623 health examinees (66,611 aged 3–17 years; 564,280 aged 18–59 years; 173,732 aged 60–99 years), and, we excluded 22,766 examinees after outlier testing. The CBC parameters (red blood cell [RBC], white blood cell [WBC], and platelet parameters) from 781,857 examinees were studied. We determined statistically significant partitions of age and sex, and calculated RIs according to the CLSI C28-A3 guidelines. RBC parameters increased with age until adulthood and decreased with age in males, but increased before puberty and then decreased with age in females. WBC and platelet counts were the highest in early childhood and decreased with age. Sex differences in each age group were noted: WBC count was higher in males than in females during adulthood, but platelet count was higher in females than in males from puberty onwards (P<0.001). Neutrophil count was the lowest in early childhood and increased with age. Lymphocyte count decreased with age after peaking in early childhood. Eosinophil count was the highest in childhood and higher in males than in females. Monocyte count was higher in males than in females (P<0.001). We provide comprehensive age- and sex-specific RIs for CBC parameters, which show dynamic changes with both age and sex.
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DOI：
10.1111/j.1751-553x.2008.01068.x
发表时间：
2009-10-01
影响因子：
3
作者：
Roshan, T. M.;Rosline, H.;Khattak, M. N.
通讯作者：
Khattak, M. N.
影响因子：
2.8
作者：
Cho, Sun-Mi;Lee, Sang-Guk;Kim, Jeong-Ho
通讯作者：
Kim, Jeong-Ho
影响因子：
120.7
作者：
Looker, AC;Dallman, PR;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
6.5
作者：
Ishiguro, A;Nakahata, T;Shimbo, T
通讯作者：
Shimbo, T
DOI：
10.1532/lh96.04010
发表时间：
2004-01-01
期刊：
Laboratory hematology : official publication of the International Society for Laboratory Hematology
影响因子：
--
作者：
Cheng, Calvino Ka-Wing;Chan, Julie;van Assendelft, Onno W
通讯作者：
van Assendelft, Onno W