Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction.
Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction.
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DOI：
10.1038/s41398-021-01475-8
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发表时间：
2021-06-30
影响因子：
6.8
通讯作者：
Ivanova SA
中科院分区：
文献类型：
--
作者：
Smirnova LP;Yarnykh VL;Parshukova DA;Kornetova EG;Semke AV;Usova AV;Pishchelko AO;Khodanovich MY;Ivanova SA
髓磷脂缺乏是精神分裂症（SZ）脑组织的重要病理特征。在这项初步研究中，全球髓鞘含量异常的白色物质（WM）和灰质（GM）的SZ患者进行了非侵入性调查，使用一种新的临床靶向定量髓鞘成像技术，快速大分子质子分数（MPF）映射。使用临床1.5T磁共振成像（MRI）扫描仪从23名健康受试者和31名SZ患者获得MPF图。采用多变量协方差分析比较了健康对照组和具有阳性和阴性先导症状的SZ患者的WM和GM的平均MPF。SZ患者在GM（p < 0.001）和WM（p = 0.02）中的MPF显著降低，相应的相对降低分别为5%和3%。相对于对照组，SZ中髓鞘含量损失的效应量分别为WM和GM的1.0和1.5。与对照组相比，以阴性症状为主的SZ患者在GM（p < 0.001）和WM（p = 0.003）中的MPF显著降低，并且相对于以阳性症状为主的患者，WM（p = 0.03）中的MPF显著降低。在SZ患者中，WM的MPF与疾病持续时间呈显著负相关（Pearson r =-0.51; p = 0.004）。这项研究表明，慢性SZ的特点是全球显微镜下脑髓鞘的WM和GM，这是与疾病的持续时间和阴性症状。SZ中的髓鞘缺乏可以通过快速MPF作图方法检测和定量。
Myelin deficiency is commonly recognized as an important pathological feature of brain tissues in schizophrenia (SZ). In this pilot study, global myelin content abnormalities in white matter (WM) and gray matter (GM) of SZ patients were non-invasively investigated using a novel clinically-targeted quantitative myelin imaging technique, fast macromolecular proton fraction (MPF) mapping. MPF maps were obtained from 23 healthy subjects and 31 SZ patients using a clinical 1.5T magnetic resonance imaging (MRI) scanner. Mean MPF in WM and GM was compared between the healthy control subjects and SZ patients with positive and negative leading symptoms using the multivariate analysis of covariance. The SZ patients had significantly reduced MPF in GM (p < 0.001) and WM (p = 0.02) with the corresponding relative decrease of 5% and 3%, respectively. The effect sizes for the myelin content loss in SZ relative to the control group were 1.0 and 1.5 for WM and GM, respectively. The SZ patients with leading negative symptoms had significantly lower MPF in GM (p < 0.001) and WM (p = 0.003) as compared to the controls and showed a significant MPF decrease in WM (p = 0.03) relative to the patients with leading positive symptoms. MPF in WM significantly negatively correlated with the disease duration in SZ patients (Pearson’s r = −0.51; p = 0.004). This study demonstrates that chronic SZ is characterized by global microscopic brain hypomyelination of both WM and GM, which is associated with the disease duration and negative symptoms. Myelin deficiency in SZ can be detected and quantified by the fast MPF mapping method.
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影响因子：
5.7
作者：
Corrigan NM;Yarnykh VL;Hippe DS;Owen JP;Huber E;Zhao TC;Kuhl PK
通讯作者：
Kuhl PK
影响因子：
2.8
作者：
Anisimov, Nikolay V.;Pavlova, Olga S.;Yarnykh, Vasily L.
通讯作者：
Yarnykh, Vasily L.
影响因子：
6.6
作者：
Falkai, Peter;Malchow, Berend;Schmitt, Andrea
通讯作者：
Schmitt, Andrea
影响因子：
11
作者：
Kelly S;Jahanshad N;Zalesky A;Kochunov P;Agartz I;Alloza C;Andreassen OA;Arango C;Banaj N;Bouix S;Bousman CA;Brouwer RM;Bruggemann J;Bustillo J;Cahn W;Calhoun V;Cannon D;Carr V;Catts S;Chen J;Chen JX;Chen X;Chiapponi C;Cho KK;Ciullo V;Corvin AS;Crespo-Facorro B;Cropley V;De Rossi P;Diaz-Caneja CM;Dickie EW;Ehrlich S;Fan FM;Faskowitz J;Fatouros-Bergman H;Flyckt L;Ford JM;Fouche JP;Fukunaga M;Gill M;Glahn DC;Gollub R;Goudzwaard ED;Guo H;Gur RE;Gur RC;Gurholt TP;Hashimoto R;Hatton SN;Henskens FA;Hibar DP;Hickie IB;Hong LE;Horacek J;Howells FM;Hulshoff Pol HE;Hyde CL;Isaev D;Jablensky A;Jansen PR;Janssen J;Jönsson EG;Jung LA;Kahn RS;Kikinis Z;Liu K;Klauser P;Knöchel C;Kubicki M;Lagopoulos J;Langen C;Lawrie S;Lenroot RK;Lim KO;Lopez-Jaramillo C;Lyall A;Magnotta V;Mandl RCW;Mathalon DH;McCarley RW;McCarthy-Jones S;McDonald C;McEwen S;McIntosh A;Melicher T;Mesholam-Gately RI;Michie PT;Mowry B;Mueller BA;Newell DT;O'Donnell P;Oertel-Knöchel V;Oestreich L;Paciga SA;Pantelis C;Pasternak O;Pearlson G;Pellicano GR;Pereira A;Pineda Zapata J;Piras F;Potkin SG;Preda A;Rasser PE;Roalf DR;Roiz R;Roos A;Rotenberg D;Satterthwaite TD;Savadjiev P;Schall U;Scott RJ;Seal ML;Seidman LJ;Shannon Weickert C;Whelan CD;Shenton ME;Kwon JS;Spalletta G;Spaniel F;Sprooten E;Stäblein M;Stein DJ;Sundram S;Tan Y;Tan S;Tang S;Temmingh HS;Westlye LT;Tønnesen S;Tordesillas-Gutierrez D;Doan NT;Vaidya J;van Haren NEM;Vargas CD;Vecchio D;Velakoulis D;Voineskos A;Voyvodic JQ;Wang Z;Wan P;Wei D;Weickert TW;Whalley H;White T;Whitford TJ;Wojcik JD;Xiang H;Xie Z;Yamamori H;Yang F;Yao N;Zhang G;Zhao J;van Erp TGM;Turner J;Thompson PM;Donohoe G
通讯作者：
Donohoe G
影响因子：
3.1
作者：
Iwatani J;Ishida T;Donishi T;Ukai S;Shinosaki K;Terada M;Kaneoke Y
通讯作者：
Kaneoke Y