Early postnatal alcohol exposure reduced the size of vibrissal barrel field in rat somatosensory cortex (SI) but did not disrupt barrel field organization.
Early postnatal alcohol exposure reduced the size of vibrissal barrel field in rat somatosensory cortex (SI) but did not disrupt barrel field organization.
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出生后早期接触酒精会减少大鼠体感皮层（SI）中振动桶状区域的大小，但不会破坏桶状区域的组织。
DOI：
10.1016/j.alcohol.2007.04.005
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Waters,RobertS
中科院分区：
文献类型：
--
作者：
Oladehin,Akinniran;Margret,CeciliaP;Maier,SusanE;Li,ChengX;Jan,TahaA;Chappell,TysonD;Waters,RobertS
在人类和动物研究中，产前酒精暴露（PAE）已被证明会改变体感皮层。在啮齿类动物中，PAE降低了新生、幼年和成年大鼠与胡须代表相关的后内侧桶子场（PMBSF）的大小，但未降低其模式。然而，PMBSF在出生时并不存在，而是在产后第一周的大脑生长高峰期首次出现。这些研究结果提出了问题，是否早期出生后酒精暴露可能会破坏桶场模式和大小，在本研究中调查的问题。出生后第4天（P4），将新生SD大鼠分为酒精（Alc）组、营养性胃控（GC）组和酒精性胃控（SC）组。从P4至P9，通过植入胃造口术管分别用溶解在牛奶中的酒精和麦芽糖糊精人工喂养Alc和GC中的大鼠幼仔。Alc组的幼崽接受牛奶中的酒精（6.0 g/kg），而GC对照组接受溶解在牛奶中的等热量当量麦芽糖糊精。SC组中的幼仔在整个实验期间与其母亲保持在一起并进行母乳喂养。在P10，对每组中的幼仔进行称重、处死，取出其大脑并称重。分离皮质半球，称重，压平，切向切片，用细胞色素氧化酶染色，并测量PMBSF。比较三组大鼠的躯干和躯干间隔区的大小，以及体重和脑重量。与对照组相比，Alc组的PMSBF桶和间隔区的大小显著较小（P<0.01），而PMBSF桶模式保持不变。与对照组相比，Alc幼仔的身体、全脑、前脑和半球重量显著降低（P<0.01）。GC组和SC组在所有因变量上均无显著差异，除了P9和P10时的体重（P<.01）。这些结果表明，出生后的酒精暴露，如产前曝光，显着影响的桶场的大小，但桶场图案的形成，表明桶场图案的形成巩固前P4。这些结果对于了解胎儿酒精谱系障碍（FASD）患儿的感觉运动缺陷是很重要的。
Prenatal alcohol exposure (PAE) has been shown to alter the somatosensory cortex in both human and animal studies. In rodents, PAE reduced the size, but not the pattern of the posteromedial barrel subfield (PMBSF) associated with the representation of the whiskers, in newborn, juvenile, and adult rats. However, the PMBSF is not present at birth, but rather first appears in the middle of the first postnatal week during the brain-growth spurt period. These findings raise questions whether early postnatal alcohol exposure might disrupt both barrel field pattern and size, questions that were investigated in the present study. Newborn Sprague-Dawley rats were assigned into alcohol (Alc), nutritional gastric control (GC), and suckle control (SC) groups on postnatal day 4 (P4). Rat pups in Alc and GC were artificially fed with alcohol and maltose-dextrin dissolved in milk, respectively, via an implant gastrostomy tube, from P4 to P9. Pups in the Alc group received alcohol (6.0g/kg) in milk, while the GC controls received isocaloric equivalent maltose-dextrin dissolved in milk. Pups in the SC group remained with their mothers and breast fed throughout the experimental period. On P10, pups in each group were weighed, sacrificed, and their brains removed and weighed. Cortical hemispheres were separated, weighed, flattened, sectioned tangentially, stained with cytochrome oxidase, and PMBSF measured. The sizes of barrels and the interbarrel septal region within PMBSF, as well as body and brain weights were compared between the three groups. The sizes of PMSBF barrel and septal areas were significantly smaller (P<.01) in Alc group compared to controls, while the PMBSF barrel pattern remained unaltered. Body, whole-brain, forebrain, and hemisphere weights were significantly reduced (P<.01) in Alc pups compared to control groups. GC and SC groups did not differ significantly in all dependent variables, except body weight at P9 and P10 (P<.01). These results suggest that postnatal alcohol exposure, like prenatal exposure, significantly influenced the size of the barrel field, but not barrel field pattern formation, indicating that barrel field pattern formation consolidated prior to P4. These results are important for understanding sensorimotor deficits reported in children suffering from fetal alcohol spectrum disorder (FASD).
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产后早期酒精暴露后神经元的差异性损失。
DOI：
10.1002/tera.1420400205
发表时间：
1989
期刊：
Teratology
影响因子：
--
作者：
Pierce,DR;Goodlett,CR;West,JR
通讯作者：
West,JR
胎儿酒精暴露和颞部脆弱性：酗酒样酒精暴露对丘脑腹外侧核的影响。
DOI：
--
发表时间：
2001
期刊：
Alcoholism, clinical and experimental research.
影响因子：
--
作者：
Livy,DJ;MaierAnd,SE;West,JR
通讯作者：
West,JR
早期接触乙醇对大鼠特定脑区蛋白质和DNA含量的影响
影响因子：
2.9
作者：
Michael W. Miller
通讯作者：
Michael W. Miller
影响因子：
2.3
作者：
BONTHIUS, DJ;GOODLETT, CR;WEST, JR
通讯作者：
WEST, JR
子宫内酒精暴露和儿童出生后四年内的功能缺陷。
DOI：
10.1002/9780470720868.ch11
发表时间：
1984
期刊：
Ciba Foundation symposium
影响因子：
--
作者：
Streissguth,AP;Barr,HM;Martin,DC
通讯作者：
Martin,DC