The effect of short-term high-caloric feeding and fasting on bone microarchitecture.
The effect of short-term high-caloric feeding and fasting on bone microarchitecture.
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DOI：
10.1016/j.bone.2021.116214
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发表时间：
2022-01
期刊：
影响因子：
4.1
通讯作者：
Miller KK
中科院分区：
文献类型：
--
作者：
Bredella MA;Fazeli PK;Bourassa J;Rosen CJ;Bouxsein ML;Klibanski A;Miller KK
慢性营养过剩和营养不足的状态都与骨骼健康受损和骨折风险增加有关，但没有关于短期控制营养挑战后骨骼微结构的数据。本研究的目的是评估短期高热量饮食和禁食对骨微结构的影响。我们假设高热量喂养和禁食都会对微结构产生负面影响。我们招募了23名成年健康受试者（13名男性，10名女性，平均年龄33.2±1.4岁，平均BMI 26.0±1.5 kg/m2）。受试者接受了为期10天的住院高热量访视（摄入热量，目标是实现7%的体重增加），之后他们回家恢复正常饮食13-18天（稳定期），然后再次入院进行为期10天的住院禁食（无热量摄入）。所有受试者在每次访视后均接受胫骨远端和桡骨远端的HRpQCT（XtremeCT，Switzerland，Brüttisellen，Switzerland），以评估体积骨密度（vBMD）、骨小梁和皮质微结构以及强度估计值。使用Wilcoxon符号秩检验进行组内比较。在高热量期间，体重平均增加6.3 ± 1.7%（p<0.0001）。胫骨远端和桡骨远端的骨参数无显著变化（p>0.05）。在稳定期内，体重显著降低-2.7 +1.9%（p<0.0001），但骨参数无变化（p>0.05）。在禁食期间，体重进一步下降了-8.8 +1.2%（p<0.0001）。在胫骨远端，总vBMD和皮质vBMD、骨小梁和皮质参数以及强度估计值显著增加（p<0.05）。在桡骨远端，总vBMD和骨小梁vBMD增加（p<0.05），而其他微结构参数或强度估计值没有变化。高热量喂养后短期禁食可改善胫骨远端的vBMD、骨微结构和强度估计，而短期高热量喂养不会改变vBMD或微结构。这些结果表明，健康个体在高热量喂养后的短期禁食改善了骨骼健康，并且这些变化可以使用HRpQCT在体内检测到。
States of chronic overnutrition and undernutrition are both associated with impaired bone health and increased fracture risk but there are no data on bone microarchitecture following short-term controlled nutritional challenges. The purpose of our study was to evaluate the impact of short-term high-caloric feeding and fasting on bone microarchitecture. We hypothesized that both high-caloric feeding and fasting would have negative effects on microarchitecture. We recruited 23 adult healthy subjects (13 males, 10 females, mean age 33.2±1.4 years, mean BMI 26.0±1.5 kg/m2). Subjects underwent an in-patient 10-day high-caloric visit (caloric intake with goal to achieve 7% weight gain), after which they went home to to resume a normal diet for 13-18 days (stabilization period), and were then readmitted for a 10-day in-patient fasting stay (no caloric intake). All subjects underwent HRpQCT (XtremeCT, Scanco Medical AG, Brüttisellen, Switzerland) of the distal tibia and distal radius after each visit to assess volumetric bone mineral density (vBMD), trabecular and cortical microarchitecture, and strength estimates. The Wilcoxon signed rank test was used to perform within group comparisons. During the high-caloric period, there was a mean increase in weight by 6.3+1.7% (p<0.0001). There were no significant changes in bone parameters in the distal tibia or distal radius (p>0.05). During the stabilization period there was a significant reduction in weight by −2.7+1.9% (p<0.0001) but no change in bone parameters (p>0.05). During the fasting period there was a further reduction in weight by −8.8+1.2% (p<0.0001). In the distal tibia, there was a significant increase in total and cortical vBMD, trabecular and cortical parameters as well as strength estimates (p<0.05). In the distal radius there was an increase in total and trabecular vBMD (p<0.05), while there were no changes in other microarchitecture parameters or strengths estimates. Short-term fasting after high-caloric feeding improves vBMD, bone microarchitecture and strength estimates of the distal tibia, while short-term high-caloric feeding does not change vBMD or microarchitecture. These results suggest that short-term fasting after high-caloric feeding in healthy individuals improves bone health and that these changes can be detected using HRpQCT in-vivo.
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影响因子：
4.1
作者：
Singhal V;Tulsiani S;Campoverde KJ;Mitchell DM;Slattery M;Schorr M;Miller KK;Bredella MA;Misra M;Klibanski A
通讯作者：
Klibanski A
影响因子：
6.2
作者：
Boutroy, Stephanie;Van Rietbergen, Bert;Delmas, Pierre D.
通讯作者：
Delmas, Pierre D.
影响因子：
6.2
作者：
Nguyen, TV;Sambrook, PN;Eisman, JA
通讯作者：
Eisman, JA
影响因子：
6.2
作者：
Parhami, F;Tintut, Y;Demer, LL
通讯作者：
Demer, LL
影响因子：
5
作者：
Knoke, JD;Barrett-Connor, E
通讯作者：
Barrett-Connor, E