Murine b7-h3 is a co-stimulatory molecule for T cell activation.

Murine b7-h3 is a co-stimulatory molecule for T cell activation.
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鼠 b7-h3 是 T 细胞激活的共刺激分子。

DOI:
10.1089/mab.2013.0052
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发表时间:
2013-12
期刊:
Monoclon Antib Immunodiagn Immunother
影响因子:
--
通讯作者:
Feng, Ping
Feng, Ping
中科院分区:
其他
文献类型:
--
作者:
He, Chunyan;Qin, Chenhao;Zhang, Xueguang;Feng, Ping

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B7家族成员B7-H3(CD276)在免疫应答中起关键作用,但其功能仍存在争议。在本研究中,我们发现小鼠B7-H3上调T细胞的增殖和细胞因子的产生。我们的研究表明,小鼠B7-H3与髓系细胞(TREM)样转录本2(TLT-2)上表达的触发受体没有相互作用。进一步研究表明,小鼠B7-H3与T细胞特异性结合,其受体不是小鼠TLT-2。此外,小鼠B7-H3在调节T细胞介导的免疫反应中是一个积极的共刺激分子。
The B7 family member B7-H3 (CD276) plays a key role during an immune response but its function remains controversial. In this study, we found that murine B7-H3 up-regulated the proliferation and cytokine production of T cells. Our study suggested that there was no interaction of murine B7-H3 with a triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2). Further studies demonstrated that mouse B7-H3 specifically bound to T cells and its receptor was not murine TLT-2. Moreover, murine B7-H3 was a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses.
DOI: 10.4049/jimmunol.173.9.5445
发表时间: 2004-11-01
影响因子: 4.4
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