Hepatic steatosis is associated with lower levels of physical activity measured via accelerometry.
Hepatic steatosis is associated with lower levels of physical activity measured via accelerometry.
复制标题
DOI：
10.1002/oby.21058
复制
发表时间：
2015-06
期刊：
影响因子：
6.9
通讯作者：
Murabito, Joanne M.
中科院分区：
文献类型：
--
作者：
Long, Michelle T.;Pedley, Alison;Massaro, Joseph M.;Hoffmann, Udo;Esliger, Dale W.;Vasan, Ramachandran S.;Fox, Caroline S.;Murabito, Joanne M.
先前关于体力活动(PA)与非酒精性脂肪性肝病的关联的研究受到对体力活动主观测量的依赖的限制。我们研究了客观测量的PA与CT定义的肝脏脂肪变性之间的关系。我们对1060名弗雷明翰心脏研究参与者进行了横断面研究，这些参与者参与了多探测器CT 2分研究，并通过加速度计对PA进行了评估。肝脏脂肪变性通过CT测量的肝脏密度来评估。我们使用多变量回归模型探讨了肝脏衰减与PA的关系。在多变量调整的模型中，我们观察到PA和肝脏衰减之间存在负相关。中度到重度PA(MVPA)每天每增加30分钟，肝脏脂肪变性的几率就会降低(OR=0.62p<；0.001)。在调整BMI(OR=0.77，p=0.05)或增值税(OR=0.83，p=0.18)后，这种相关性减弱，不再具有统计学意义。符合国家PA推荐的每周进行≥150分钟的参与者，即使在调整了体重指数(OR=0.63，p=0.007)或增值税(OR=0.67，p=0.03)后，发生肝脏脂肪变性的几率也是最低的。PA与肝脏脂肪变性呈负相关。符合国家PA指南的参与者肝脏脂肪变性的患病率最低。
Prior studies on the association of physical activity (PA) and non-alcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA and hepatic steatosis defined by computed tomography (CT). We conducted a cross-sectional study of 1060 Framingham Heart Study participants who participated in the Multi-Detector CT 2 substudy and who underwent assessment of PA via accelerometry. Hepatic steatosis was estimated by liver attenuation, as measured by CT. We explored the relationship between liver attenuation and PA using multivariable regression models. In multivariable-adjusted models, we observed an inverse association between PA and liver attenuation. Each 30 min/day increase in moderate-to-vigorous PA (MVPA) was associated with a reduced odds of hepatic steatosis (OR=0.62, p<0.001). This association was attenuated and no longer statistically significant after adjustment for BMI (OR=0.77, p=0.05) or VAT (OR=0.83, p=0.18). Participants who met the national PA recommendations of engaging in ≥150 minutes/week of MVPA, had the lowest odds of hepatic steatosis, even after adjusting for BMI (OR=0.63, p=0.007) or VAT (OR=0.67, p=0.03). There is an inverse association between PA and hepatic steatosis. Participants who met the national PA guidelines had the lowest prevalence of hepatic steatosis.
登录
查看更多内容
DOI：
10.1097/00075197-200111000-00006
发表时间：
2001-11-01
影响因子：
3.1
作者：
Blaak, E
通讯作者：
Blaak, E
DOI：
10.1001/jama.2010.1505
发表时间：
2010-10-27
期刊：
JAMA
影响因子：
--
作者：
Goodpaster BH;Delany JP;Otto AD;Kuller L;Vockley J;South-Paul JE;Thomas SB;Brown J;McTigue K;Hames KC;Lang W;Jakicic JM
通讯作者：
Jakicic JM
直接与自我报告措施评估成人体育锻炼的比较：系统评价。
DOI：
10.1186/1479-5868-5-56
发表时间：
2008-11-06
影响因子：
8.7
作者：
Prince, Stephanie A.;Adamo, Kristi B.;Hamel, Meghan E.;Hardt, Jill;Gorber, Sarah Connor;Tremblay, Mark
通讯作者：
Tremblay, Mark
影响因子：
16.2
作者：
Dunstan DW;Kingwell BA;Larsen R;Healy GN;Cerin E;Hamilton MT;Shaw JE;Bertovic DA;Zimmet PZ;Salmon J;Owen N
通讯作者：
Owen N
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH