Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis.
Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis.
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DOI：
10.1016/j.jaci.2009.04.045
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发表时间：
2009-07
影响因子：
14.2
通讯作者：
Schleimer, Robert P.
中科院分区：
文献类型：
--
作者：
Tieu, David D.;Kern, Robert C.;Schleimer, Robert P.
慢性鼻窦炎（CRS）的特征是鼻腔和副鼻窦粘膜的慢性症状性炎症，是美国最常见的慢性疾病之一，估计患病率超过总人口的10%。尽管CRS的发病机制尚不清楚，但有证据表明细菌和真菌的作用，以及上呼吸道和鼻窦中存在强大的适应性免疫反应。最近对CRS以及其他几种皮肤和呼吸上皮疾病的研究发现，上皮免疫屏障功能的缺陷可能会损害宿主与外部免疫刺激之间的相互作用。最近的研究表明，抗菌S100蛋白，特别是牛皮癣蛋白和钙保护蛋白的表达减少可能导致CRS患者对细菌和真菌定植的易感性增加。本综述的主要重点是强调当前的文献，这些文献表明，在CRS患者中，广泛的上皮源性基因表达缺陷可能导致屏障受损，随后导致宿主对环境因子的功能失调免疫反应。
Chronic rhinosinusitis (CRS) is characterized by a chronic symptomatic inflammation of the nasal and paranasal sinus mucosae and is one of the most frequently reported chronic diseases in the United States, with an estimated prevalence of greater than 10% of the general population. Although the pathogenesis of CRS remains poorly understood, there is evidence for a role of bacteria and fungi, as well as the presence of a robust adaptive immune response in the upper airways and sinuses. Recent studies of CRS, as well as several other diseases in the skin and respiratory epithelium, have uncovered evidence that deficiencies in epithelial immune barrier function might compromise the interaction between the host and external immune stimuli. Recent studies suggest the hypothesis that reduced expression of antimicrobial S100 proteins, particularly psoriasin and calprotectin, might lead to increased susceptibility to bacterial and fungal colonization in patients with CRS. The main emphasis of this review will be to highlight the current literature that suggests that a defect in the expression of a broad set of epithelially derived genes might lead to barrier compromise and subsequently a dysfunctional host immune response to environmental agents in patients with CRS.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
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影响因子：
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作者：
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