Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation.
Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation.
复制标题
DOI：
10.1126/sciadv.abq7469
复制
发表时间：
2022-10-28
期刊：
影响因子：
13.6
通讯作者：
Gutruf, Philipp
中科院分区：
文献类型：
--
作者：
Ausra, Jokubas;Madrid, Micah;Yin, Rose T.;Hanna, Jessica;Arnott, Suzanne;Brennan, Jaclyn A.;Peralta, Roberto;Clausen, David;Bakall, Jakob A.;Efimov, Igor R.;Gutruf, Philipp
心脏功能的监测和控制对于心血管病理生理学的研究和开发挽救生命的疗法至关重要。然而，目前对自由活动的小动物受试者（其提供多种基因型和表型）的心脏进行慢性刺激是困难的。具体来说，目前不可能以高空间和时间分辨率实时控制心脏功能。在这里，我们介绍了一种无线无电池设备，具有板载计算功能，可通过多部位刺激进行实时心脏控制，从而实现整个啮齿动物心脏的光遗传学调制。机器学习引导的超薄阵列设计实现了生物界面与心脏的无缝集成。在自由移动的动物中演示了长期起搏、记录和机载计算。该设备类别支持新的心力衰竭模型，并通过提供在受试者一生中持续控制心脏功能的方法，提供一个在长期时间尺度上测试实时治疗范例的平台。推出了用于啮齿动物的无线植入式心脏监测仪，具有机载计算和多站点刺激功能。
Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning–guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject. Wireless implantable cardiac monitors for rodents are introduced that feature on-board computation and multisite stimulation.
登录
查看更多内容
影响因子：
16.6
作者：
Ausra J;Munger SJ;Azami A;Burton A;Peralta R;Miller JE;Gutruf P
通讯作者：
Gutruf P
影响因子：
7.9
作者：
Burton A;Won SM;Sohrabi AK;Stuart T;Amirhossein A;Kim JU;Park Y;Gabros A;Rogers JA;Vitale F;Richardson AG;Gutruf P
通讯作者：
Gutruf P
影响因子：
4
作者：
Lu, Nanshu;Wang, Xi;Vlassak, Joost
通讯作者：
Vlassak, Joost
影响因子：
48
作者：
Bruegmann, Tobias;Malan, Daniela;Sasse, Philipp
通讯作者：
Sasse, Philipp
影响因子：
4
作者：
Gutruf, Philipp;Walia, Sumeet;Bhaskaran, Madhu
通讯作者：
Bhaskaran, Madhu