Smoking-related cue-induced brain activation in adolescent light smokers.
Smoking-related cue-induced brain activation in adolescent light smokers.
复制标题
DOI：
10.1016/j.jadohealth.2010.09.016
复制
发表时间：
2011-01
影响因子：
7.6
通讯作者：
Simpson, Gregory V.
中科院分区：
文献类型：
--
作者：
Rubinstein, Mark L.;Luks, Tracy L.;Moscicki, Anna-Barbara;Dryden, Wendy;Rait, Michelle A.;Simpson, Gregory V.
使用功能磁共振成像，我们检查了低水平尼古丁暴露的青少年（轻度吸烟者）在对吸烟相关刺激的反应中是否表现出与成瘾有关的区域的神经激活。来自旧金山湾区的12名青少年轻度吸烟者（13至17岁，每天抽1至5支烟）和12名不吸烟者（13至17岁，从不吸烟）接受了功能磁共振成像扫描。在扫描过程中，他们观看了几块吸烟和控制线索的照片。吸烟线索包括吸烟的人的照片和与吸烟有关的物品，如打火机和烟灰缸。中性线索包括日常物品和从事日常活动的人。对于吸烟者来说，吸烟线索比中性线索在中边缘奖励回路(左前扣带（T=7.88, p< 0.001）、右海马（T=6.62, p< 0.001）和右海马旁回（T=4.70, p< 0.001）中引发更大的激活。我们发现，在左侧和右侧额内侧眶区，吸烟线索激活与中性线索激活相比（T=5.09, p<.001和T=3.94, p=.001），这可能是青少年独有的。非吸烟者在吸烟相关线索和中性线索之间的激活没有显着差异。我们的研究发现，吸烟线索在青少年轻度吸烟者的大脑中产生了激活，这一区域在成人和重度青少年吸烟者中同样存在，这表明，即使在低水平吸烟的情况下，青少年对吸烟线索的反应也会增强。这篇论文补充了现有的文献，表明尼古丁依赖可能始于接触低水平的尼古丁，强调了对青少年吸烟者进行早期干预的必要性。
Using fMRI, we examined whether or not adolescents with low levels of nicotine exposure (light smokers) display neural activation in areas shown to be involved with addiction in response to smoking-related stimuli. Twelve adolescent light smokers (aged 13 to17, smoked 1 to 5 cigarettes per day) and 12 non-smokers (ages 13 to 17, never smoked a cigarette) from the San Francisco Bay Area underwent fMRI scanning. During scanning they viewed blocks of photographic smoking and control cues. Smoking cues consisted of pictures of people smoking cigarettes and smoking-related objects such as lighters and ashtrays. Neutral cues consisted of everyday objects and people engaged in everyday activities. For smokers, smoking cues elicited greater activation than neutral cues in the mesolimbic reward circuit (left anterior cingulate (T=7.88, p<.001), right hippocampus (T=6.62, p<.001) and right parahippocampal gyrus (T=4.70, p<.001)). We found activation from smoking cues versus neutral cues within both the left and right frontal medial orbital regions (T=5.09, p<.001 and T=3.94, p=.001 respectively), which may be unique to adolescents. Non-smokers showed no significant difference in activation between smoking-related cues and neutral cues. Our finding that smoking cues produced activation in adolescent light smokers in brain regions seen in adult and heavy teen smokers suggests that even at low levels of smoking, adolescents exhibit heightened reactivity to smoking cues. This paper adds to the existing literature suggesting that nicotine dependence may begin with exposure to low levels of nicotine, underscoring the need for early intervention among adolescent smokers.
登录
查看更多内容
影响因子：
7.6
作者：
McClernon, FJ;Hiott, FB;Rose, JE
通讯作者：
Rose, JE
影响因子：
7.6
作者：
McBride, Dharma;Barrett, Sean P.;Dagher, Alain
通讯作者：
Dagher, Alain
影响因子：
56.9
作者：
KOOB, GF;BLOOM, FE
通讯作者：
BLOOM, FE
影响因子：
7.6
作者：
Franklin, Teresa R.;wang, Ze;Childress, Anna Rose
通讯作者：
Childress, Anna Rose
影响因子：
--
作者：
Brody, AL;Mandelkern, MA;Jarvik, ME
通讯作者：
Jarvik, ME