FADS Polymorphism, Omega-3 Fatty Acids and Diabetes Risk: A Systematic Review.
FADS Polymorphism, Omega-3 Fatty Acids and Diabetes Risk: A Systematic Review.
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DOI：
10.3390/nu10060758
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发表时间：
2018-06-13
期刊：
影响因子：
5.9
通讯作者：
Livingstone KM
中科院分区：
文献类型：
--
作者：
Brayner B;Kaur G;Keske MA;Livingstone KM
N-3长链多不饱和脂肪酸(LC n-3 PUFA)在降低2型糖尿病(T2 DM)风险方面的作用尚不清楚。LCn-3多不饱和脂肪酸的合成需要由FADS基因编码的脂肪酸去饱和酶。目前尚不清楚FADS基因多态性和膳食脂肪酸摄入量是否会影响血浆或红细胞膜脂肪酸分布，从而影响患T2 DM的风险。因此，这项系统性综述的目的是评估FADS基因多态性对T2 DM风险的影响的现有证据，并了解其与血清/红细胞和膳食LC n-3多不饱和脂肪酸的关系。使用PubMed、Embase、Cochrane和Scope数据库进行了系统的搜索。共有五项研究符合纳入标准，列入本次审查。本综述证实FADS基因多态性可能改变血浆脂肪酸组成，在T2 DM的发生发展中起保护作用。在一项研究中，血清和红细胞LCn-3PUFA水平与T2 DM的风险无关，而饮食摄入LCn-3PUFA与T2 DM的风险降低有关。Lcn-3多不饱和脂肪酸摄入对FADS基因多态性与T2 DM相关性的影响值得进一步研究。
The role of n-3 long chain polyunsaturated fatty acids (LC n-3 PUFA) in reducing the risk of type 2 diabetes (T2DM) is not well established. The synthesis of LC n-3 PUFA requires fatty acid desaturase enzymes, which are encoded by the FADS gene. It is unclear if FADS polymorphism and dietary fatty acid intake can influence plasma or erythrocyte membrane fatty acid profile and thereby the risk of T2DM. Thus, the aim of this systematic review was to assess the current evidence for an effect of FADS polymorphism on T2DM risk and understand its associations with serum/erythrocyte and dietary LC n-3 PUFA. A systematic search was performed using PubMed, Embase, Cochrane and Scopus databases. A total of five studies met the inclusion criteria and were included in the present review. This review identified that FADS polymorphism may alter plasma fatty acid composition and play a protective role in the development of T2DM. Serum and erythrocyte LC n-3 PUFA levels were not associated with risk of T2DM, while dietary intake of LC n-3 PUFA was associated with lower risk of T2DM in one study only. The effect of LC n-3 PUFA consumption on associations between FADS polymorphism and T2DM warrants further investigation.
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影响因子：
158.5
作者：
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通讯作者：
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影响因子：
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Vohl MC
DOI：
10.1016/j.plefa.2014.10.008
发表时间：
2015-03
影响因子：
3
作者：
Scholtz, S. A.;Kerling, E. H.;Shaddy, D. J.;Li, S.;Thodosoff, J. M.;Colombo, J.;Carlson, S. E.
通讯作者：
Carlson, S. E.