Altered premotor cortical oscillations during repetitive movement in persons with Parkinson's disease.
Altered premotor cortical oscillations during repetitive movement in persons with Parkinson's disease.
复制标题
DOI：
10.1016/j.bbr.2016.09.036
复制
发表时间：
2017-01-15
影响因子：
2.7
通讯作者：
MacKinnon CD
中科院分区：
文献类型：
--
作者：
Stegemöller EL;Allen DP;Simuni T;MacKinnon CD
前运动区在控制重复运动中起着关键作用。虽然研究表明，运动相关的振荡是异常的，在帕金森氏病（PD）患者的重复运动，有有限的研究检查运动前区的贡献，如对侧背侧运动前区（PMd）和补充运动区（SMA），这种损害。本研究比较了帕金森病患者和对照组患者运动前区的运动相关振荡。研究了9名PD停药和用药的参与者以及9名匹配的对照参与者。参与者进行暗示食指运动。频谱功率分别来自对侧PMd和SMA区域上的电极FC 3/FC 4和Cz的脑电图记录。与对照受试者相比，PD参与者在停药和用药条件下，电极FC 3/FC 4（对侧PMd）上与运动相关的α和β频段振荡受到抑制，特别是在较高的运动速率下。PD组和对照组之间从Cz（SMA）记录的运动相关振荡模式相似。这表明对侧PMD区域可能优先参与外部提示重复运动的控制，并且这种活动的变化可能导致PD患者重复手指运动以更高的速率恶化。
Premotor areas play a critical role in the control of repetitive movements. While research has shown that movement-related oscillations are abnormal during repetitive movements in persons with Parkinson’s disease (PD), there is limited research examining the contribution of premotor areas, such as the contralateral dorsal premotor area (PMd) and supplementary motor area (SMA), to this impairment. This study compared movement-related oscillations over premotor regions between participants with PD and control participants. Nine participants with PD off and on medication and nine matched control participants were studied. Participants performed cued index finger movements. Spectral power was derived from electroencephalographic recordings from electrodes FC3/FC4 and Cz over the regions of the contralateral PMd and SMA respectively. Movement-related alpha and beta band oscillations were suppressed over electrode FC3/FC4 (contralateral PMd) in participants with PD, particularly at higher movement rates, in both the off and on medication conditions compared to control subjects. The pattern of movement-related oscillations recorded from Cz (SMA) was similar between PD and control groups. This would suggest that the region of the contralateral PMd may be preferentially involved with the control of externally cued repetitive movements and that changes in this activity may contribute to the deterioration of repetitive finger movements at higher rates in persons with PD.
登录
查看更多内容
影响因子：
8.6
作者：
Vercruysse, Sarah;Spildooren, Joke;Nieuwboer, Alice
通讯作者：
Nieuwboer, Alice
影响因子：
14.5
作者：
Catalan, MJ;Ishii, K;Hallett, M
通讯作者：
Hallett, M
影响因子：
4.4
作者：
Jenkins, IH;Passingham, RE;Brooks, DJ
通讯作者：
Brooks, DJ
DOI：
10.1016/j.clinph.2015.05.014
发表时间：
2016-01
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Stegemöller EL;Allen DP;Simuni T;MacKinnon CD
通讯作者：
MacKinnon CD
影响因子：
8.6
作者：
Stegemoeller, Elizabeth L.;Simuni, Tanya;MacKinnon, Colum
通讯作者：
MacKinnon, Colum