Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease.
Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease.
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DOI：
10.1016/j.clinph.2015.05.014
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
MacKinnon CD
中科院分区：
文献类型：
--
作者：
Stegemöller EL;Allen DP;Simuni T;MacKinnon CD
帕金森氏病(PD)患者的重复运动受损与幅度降低、矛盾的加速、在较高运动率下的犹豫或停顿有关。这项研究考察了运动速度和药物对帕金森病患者运动相关皮质振荡的影响。对9名帕金森病患者进行了停药和服药研究，并与9名对照组参与者进行了比较。参与者根据1至3赫兹的音调进行食指运动。运动相关的振荡来自于在休息、倾听或同步运动时对侧感觉运动皮质(S1/M1)区域的脑电记录。静息状态下，与对照组相比，帕金森病患者对侧S1/M1区域记录的频谱功率在α频段增加，在β频段减少。在运动期间，与对照组相比，帕金森病组停药和服药后的α和β频段功率水平相对于基线显著降低。在接近2赫兹的运动速度下，运动幅度降低和加速与α和β频段振荡的异常抑制和持续去同步化有关。帕金森病患者α和β频段的运动皮质振荡受到异常抑制，尤其是在较高的运动速度时。这些发现有助于理解帕金森病患者重复运动受损的机制。
Impaired repetitive movement in persons with Parkinson's disease (PD) is associated with reduced amplitude, paradoxical hastening and hesitations or arrest at higher movement rates. This study examined the effects of movement rate and medication on movement-related cortical oscillations in persons with PD. Nine participants with PD were studied off and on medication and compared to nine control participants. Participants performed index finger movements cued by tones from 1 to 3 Hz. Movement-related oscillations were derived from electroencephalographic recordings over the region of the contralateral senorimotor cortex (S1/M1) during rest, listening, or synchronized movement. At rest, spectral power recorded over the region of the contralateral S1/M1 was increased in the alpha band and decreased in the beta band in participants with PD relative to controls. During movement, the level of alpha and beta band power relative to baseline was significantly reduced in the PD group, off and on medication, compared to controls. Reduced movement amplitude and hastening at movement rates near 2 Hz was associated with abnormally suppressed and persistent desynchronization of oscillations in alpha and beta bands. Motor cortical oscillations in the alpha and beta bands are abnormally suppressed in PD, particularly during higher rate movements. These findings contribute to the understanding of mechanisms underlying impaired repetitive movement in PD.
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