Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery.
Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery.
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DOI：
10.1016/j.yfrne.2017.10.004
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发表时间：
2018-10
影响因子：
7.4
通讯作者：
Albers HE
中科院分区：
文献类型：
--
作者：
Song Z;Albers HE
催产素（OT）和精氨酸加压素（AVP）在大脑中起作用，以调节社会认知/社会行为，并在外周影响各种生理过程。虽然OT和AVP及其受体的化学结构非常相似，但OT和AVP可以具有不同的甚至相反的作用。在这里，我们回顾了越来越多的证据表明，外源性施用和内源性释放的OT和AVP可以激活彼此的经典受体（即，串扰），并检查OT和AVP的突触和非突触释放后的受体串扰有助于它们在脑和外周中的不同作用的可能性。了解OT和AVP受体之间的相互作用的后果对于确定这些肽如何控制社会认知和行为以及开发治疗各种精神疾病的药物非常重要。
Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery to influence a variety of physiological processes. Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions. Here, we review the increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other’s canonical receptors (i.e., cross-talk) and examine the possibility that receptor cross-talk following the synaptic and non-synaptic release of OT and AVP contributes to their distinct roles in the brain and periphery. Understanding the consequences of cross-talk between OT and AVP receptors will be important in identifying how these peptides control social cognition and behavior and for the development of drugs to treat a variety of psychiatric disorders.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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