Anticipating agoraphobic situations: the neural correlates of panic disorder with agoraphobia
Anticipating agoraphobic situations: the neural correlates of panic disorder with agoraphobia
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预测广场恐惧症情况：恐慌症与广场恐惧症的神经相关性
DOI：
10.1017/s0033291713003085
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发表时间：
2014
影响因子：
6.9
通讯作者：
Ströhle A
中科院分区：
文献类型：
--
作者：
Wittmann A;Schlagenhauf F;Guhn A;Lueken U;Stoy M;Bermpohl F;Fydrich T;Pfleiderer B;Bruhn H;Gerlach AL;Kircher T;Straube B;Wittchen HU;Arolt V;Heinz A;Ströhle A
背景惊恐障碍伴广场恐怖症的特征是在逃生可能困难的情况下惊恐发作和焦虑。然而，专门针对广场恐怖症的神经影像学研究很少。在这里，我们使用功能性磁共振成像（fMRI）与障碍特定的刺激，探讨广场恐怖症的神经基板。MethodWe比较了72例惊恐障碍与广场恐怖症与72名匹配的健康对照组在3-T功能性磁共振成像研究的神经激活。为了隔离广场恐惧症的具体变化，我们测试的预期和感知的广场恐惧症的具体刺激集的影响。在功能磁共振成像，48广场恐惧症的具体和48中性图片随机提出和没有预期的刺激，表明随后的图片的内容（Westphal paradigm）.ResultsDuring预期广场恐惧症的具体图片，更强的激活被发现在双侧腹侧纹状体和左侧纹状体的患者与对照组相比。有没有组的差异在感知阶段的广场恐惧症的具体picture.ConclusionsThis研究揭示了更强的区域特异性激活的患者患有恐慌症与广场恐惧症的预期广场恐惧症的具体刺激。患者似乎更强烈地处理这些刺激基于个人的显着性。腹侧纹状体和纹状体的过度激活时，预期广场恐怖症的具体情况可能是广场恐怖症的中枢神经功能相关。关于广场恐怖症情境的预期和感知过程的神经相关性的知识将有助于优化和评估惊恐障碍和广场恐怖症患者的治疗，如暴露疗法。
BackgroundPanic disorder with agoraphobia is characterized by panic attacks and anxiety in situations where escape might be difficult. However, neuroimaging studies specifically focusing on agoraphobia are rare. Here we used functional magnetic resonance imaging (fMRI) with disorder-specific stimuli to investigate the neural substrates of agoraphobia.MethodWe compared the neural activations of 72 patients suffering from panic disorder with agoraphobia with 72 matched healthy control subjects in a 3-T fMRI study. To isolate agoraphobia-specific alterations we tested the effects of the anticipation and perception of an agoraphobia-specific stimulus set. During fMRI, 48 agoraphobia-specific and 48 neutral pictures were randomly presented with and without anticipatory stimulus indicating the content of the subsequent pictures (Westphal paradigm).ResultsDuring the anticipation of agoraphobia-specific pictures, stronger activations were found in the bilateral ventral striatum and left insula in patients compared with controls. There were no group differences during the perception phase of agoraphobia-specific pictures.ConclusionsThis study revealed stronger region-specific activations in patients suffering from panic disorder with agoraphobia in anticipation of agoraphobia-specific stimuli. Patients seem to process these stimuli more intensively based on individual salience. Hyperactivation of the ventral striatum and insula when anticipating agoraphobia-specific situations might be a central neurofunctional correlate of agoraphobia. Knowledge about the neural correlates of anticipatory and perceptual processes regarding agoraphobic situations will help to optimize and evaluate treatments, such as exposure therapy, in patients with panic disorder and agoraphobia.
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影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
3.1
作者：
Menon, Vinod;Uddin, Lucina Q.
通讯作者：
Uddin, Lucina Q.
影响因子：
--
作者：
Kessler, RC;Chiu, WT;Walters, EE
通讯作者：
Walters, EE
影响因子：
2.3
作者：
Herwig, Uwe;Abler, Birgit;Erk, Susanne
通讯作者：
Erk, Susanne
小儿焦虑症激励预期期间纹状体功能的改变。
DOI：
10.1176/appi.ajp.2011.11010006
发表时间：
2012-02
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Guyer AE;Choate VR;Detloff A;Benson B;Nelson EE;Perez-Edgar K;Fox NA;Pine DS;Ernst M
通讯作者：
Ernst M