Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury.
Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury.
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DOI：
10.1016/j.nbd.2008.07.015
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发表时间：
2008-11
影响因子：
6.1
通讯作者：
Jakowec MW
中科院分区：
文献类型：
--
作者：
Vucković MG;Wood RI;Holschneider DP;Abernathy A;Togasaki DM;Smith A;Petzinger GM;Jakowec MW
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse serves as a model of basal ganglia injury and Parkinson’s disease. The present study investigated the effects of MPTP-induced lesioning on associative memory, conditioned fear, and affective behavior. Male C57BL/6 mice were administered saline or MPTP and separate groups were evaluated at either 7 or 30 days post-lesioning. In the social transmission of food preference test, mice showed a significant decrease in preference for familiar food 30 days post-MPTP compared to controls. Mice at both 7 and 30 days post-MPTP-lesioning had increased fear extinction compared to controls. HPLC analysis of tissues homogenates showed dopamine and serotonin were depleted in the striatum, frontal cortex, and amygdala. No changes in anxiety or depression were detected by the tail suspension, sucrose preference, light-dark preference, or hole-board tests. In conclusion, acute MPTP-lesioning regimen in mice causes impairments in associative memory and conditioned fear, no mood changes, and depletion of dopamine and serotonin throughout the brain.
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影响因子：
2.9
作者：
HELMSTETTER, FJ
通讯作者：
HELMSTETTER, FJ
影响因子：
14.5
作者：
Bowers, Dawn;Miller, Kimberly;Okun, Michael
通讯作者：
Okun, Michael
影响因子：
1.9
作者：
Greba, Q;Kokkinidis, L
通讯作者：
Kokkinidis, L
DOI：
10.1111/j.1749-6632.1999.tb09312.x
发表时间：
1999-01-01
期刊：
ADVANCING FROM THE VENTRAL STRIATUM TO THE EXTENDED AMYGDALA
影响因子：
--
作者：
Guarraci, FA;Frohardt, RJ;Karp, BS
通讯作者：
Karp, BS
影响因子：
4.8
作者：
BROWN, MR;RIVIER, C;VALE, W
通讯作者：
VALE, W