Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits.

Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits.
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DOI:
10.1016/bs.irn.2020.11.008
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发表时间:
2021
影响因子:
--
通讯作者:
Kwan AC
Kwan AC
中科院分区:
医学3区
文献类型:
--
作者:
Yang JH;Kwan AC

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内侧次级运动皮层(MOs 或 M2)构成啮齿动物内侧额叶皮层的背侧。我们之前提出,MO 的功能是将先前条件(包括感官刺激和先前选择)与即将发生的动作联系起来。在这篇综述中,我们重点关注 MO 与其他皮质和皮质下区域之间的远程通路。我们强调三个回路:(1)与视觉和听觉皮层的连接,这对于感知输入的预测编码至关重要; (2) 与运动皮层和脑干的连接,负责自上而下、上下文相关的运动调节; (3)与压后皮质、眶额皮质和基底神经节的连接促进基于奖励的学习。这些远程电路共同允许 MO 广播选择信号以进行反馈并影响决策过程。
Medial secondary motor cortex (MOs or M2) constitutes the dorsal aspect of the rodent medial frontal cortex. We previously proposed that the function of MOs is to link antecedent conditions, including sensory stimuli and prior choices, to impending actions. In this review, we focus on the long-range pathways between MOs and other cortical and subcortical regions. We highlight three circuits: (1) connections with visual and auditory cortices that are essential for predictive coding of perceptual inputs; (2) connections with motor cortex and brainstem that are responsible for top-down, context-dependent modulation of movements; (3) connections with retrosplenial cortex, orbitofrontal cortex, and basal ganglia that facilitate reward-based learning. Together, these long-range circuits allow MOs to broadcast choice signals for feedback and to bias decision-making processes.
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