Brain mechanisms of chronic pain: critical role of translational approach.
Brain mechanisms of chronic pain: critical role of translational approach.
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DOI：
10.1016/j.trsl.2021.06.004
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Apkarian AV
中科院分区：
文献类型：
--
作者：
Barroso J;Branco P;Apkarian AV
慢性疼痛是世界范围内致残的主要原因，其患病率在未来几十年可能会增加。对慢性疼痛的治疗仍然不足，治疗进展没有取得与许多慢性疾病相当的进展，从而加剧了对该疾病未来负担的关注。与此同时，即使经过几十年的深入研究，对慢性疼痛的潜在病理生理学仍然知之甚少。我们认为，推进我们目前对慢性疼痛的理解需要机制明确、假设驱动和临床聚焦的模型。在这篇综述中，我们重点介绍了过去几十年的一些主要发现，这些发现有助于目前对慢性疼痛的大脑机制的了解，以及如何通过反向转化研究方法实现这些进展。我们认为，这种方法在慢性疼痛领域是必不可少的，以便产生新的科学假设，探索生理机制，制定治疗策略，并将研究结果转化为有希望的人体临床试验。
Chronic pain is a leading cause of disability worldwide and its prevalence is likely to increase over the next decades. Treatment for chronic pain remains insufficient and therapeutical advances have not made comparable progress with that for many chronic disorders, thus amplifying the concern on the future burden of the disease. At the same time, and even after decades of intense research, the underlying pathophysiology of chronic pain remains minimally understood. We believe advancing our current understanding of chronic pain requires mechanistically explicit, hypothesis-driven, and clinically focused models. In this review we highlight some of the main findings over the last decades that have contributed to the present knowledge of brain mechanisms of chronic pain, and how such advances were possible due to a reverse translational research approach. We argue that this approach is essential in the chronic pain field, in order to generate new scientific hypotheses, probe physiological mechanisms, develop therapeutic strategies and translate findings back into promising human clinical trials.
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