The participation of a neurocircuit from the paraventricular thalamus to amygdala in the depressive like behavior
The participation of a neurocircuit from the paraventricular thalamus to amygdala in the depressive like behavior
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从室旁丘脑到杏仁核的神经回路参与抑郁样行为
DOI：
10.1016/j.neulet.2010.11.007
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发表时间：
2011-01
影响因子：
2.5
通讯作者：
刘星
中科院分区：
文献类型：
--
作者：
朱磊;吴亮;余波;刘星
抑郁症是一种由遗传、生化、环境和心理因素引起的神经心理疾病。然而，参与其中的神经回路尚不清楚。我们引入强迫游泳试验（FST）作为抑郁样行为的模型。本研究观察了丘脑室旁核（PVT）投射参与FST的过程。逆行追踪结合免疫荧光检测c-fos。结果表明，FST可显著增加PVT和中央杏仁核（CE）神经元c-fos的表达。在PVT和CE中的这些激活的神经元群体也被CE中注射的逆行示踪剂FG标记，这表明PVT的激活通过将信息传递给CE而参与这种抑郁样行为。
Depression is a neuropsychological disease derived from genetic, biochemical, environmental, and psychological factors. However the neurocircuits involved in it are not clear. We introduced the forced swimming test (FST) as a model of the depressive like behavior. In our study, the participation of projections from paraventricular nucleus of the thalamus (PVT) in FST was detected. The retrograde tracing combined with immunofluorescent detection of c-fos was used. Our results showed that the FST greatly increased the c-fos level in PVT and the central amygdale (CE) neurons. These populations of activated neurons in the PVT and the CE were also labeled by the retrograde tracer FG injected in the CE, suggesting that the activation of PVT was involved in this depressive like behavior by relaying information to the CE.
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影响因子：
2.9
作者：
L. Hansen-Trench;S. Barron
通讯作者：
L. Hansen-Trench;S. Barron
影响因子：
2.9
作者：
I. V. Viglinskaya;D. Overstreet;O. Kashevskaya;B. A. Badishtov;A. Kampov-Polevoy;S. Seredenin;J. Halikas
通讯作者：
I. V. Viglinskaya;D. Overstreet;O. Kashevskaya;B. A. Badishtov;A. Kampov-Polevoy;S. Seredenin;J. Halikas
影响因子：
3.7
作者：
Collins A;Hill LE;Chandramohan Y;Whitcomb D;Droste SK;Reul JM
通讯作者：
Reul JM
影响因子：
2.3
作者：
Parsons, MP;Li, S;Kirouac, GJ
通讯作者：
Kirouac, GJ
影响因子：
2.3
作者：
F. Hall;F. Hall;L. Wilkinson;T. Humby;T. Robbins
通讯作者：
F. Hall;F. Hall;L. Wilkinson;T. Humby;T. Robbins