Organization, barrier function and antimicrobial lipids of the oral mucosa.
Organization, barrier function and antimicrobial lipids of the oral mucosa.
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DOI：
10.1111/ics.12038
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发表时间：
2013-06
影响因子：
2.3
通讯作者：
Wertz PW
中科院分区：
文献类型：
--
作者：
Dawson DV;Drake DR;Hill JR;Brogden KA;Fischer CL;Wertz PW
当一个人从皮肤穿过嘴唇的朱红色区域进入口腔时，就会遇到口腔粘膜。口腔粘膜由结缔组织组成，称为固有层，由复层鳞状上皮覆盖。在硬腭和牙龈的区域，上皮象表皮一样角化。在口腔区域、口底和舌下，上皮细胞是非角化的。舌背上皮是一种特化上皮，但可以近似为角化和非角化上皮的马赛克。非角化性上皮区不形成角质层。DNA完整的细胞核保留在表层细胞中。在所有区域，上皮的外部提供了保护性的渗透性屏障，这一屏障因地区而异。口腔粘膜表面的抗菌脂是天然免疫的组成部分。
As one moves from the skin across the vermilion region of the lip and into the oral cavity the oral mucosa is encountered. The oral mucosa consists of connective tissue known as the lamina propria covered by a stratified squamous epithelium. In the regions of the hard palate and gingiva the epithelium is keratinized like the epidermis. In the buccal region, the floor of the mouth and the underside of the tongue the epithelium is nonkeratinized. The epithelium on the dorsum of the tongue is a specialized epithelium but can be approximated as a mosaic of keratinized and nonkeratinized epithelia. The nonkeratinized epithelial regions do not produce a stratum corneum. Nuclei with intact DNA are retained in the superficial cells. In all regions the outer portions of the epithelium provides a protective permeability barrier, which varies regionally. Antimicrobial lipids at the surfaces of the oral mucosa are an integral part of innate immunity.
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影响因子：
10.3
作者：
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通讯作者：
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影响因子：
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