Left-shifting prism adaptation boosts reward-based learning.
Left-shifting prism adaptation boosts reward-based learning.
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DOI：
10.1016/j.cortex.2018.09.021
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Wassermann EM
中科院分区：
文献类型：
--
作者：
Schintu S;Freedberg M;Alam ZM;Shomstein S;Wassermann EM
视觉空间认知具有内在的偏侧化倾向。这种偏差的方向和幅度的个体差异与不对称的D2/3多巴胺结合和多巴胺系统基因型有关。多巴胺水平影响基于反馈的学习，多巴胺信号的不对称性与奖赏和惩罚的差异学习有关。左半球的高D2结合与奖励偏好有关。棱镜适应（PA）是一种简单的感觉运动技术，它根据偏差的方向调节视觉空间偏差。左偏棱镜适应（LPA）在健康受试者中诱导了偏性。因此，右侧空间的显著性沿着左半球多巴胺能活动的增加是可能的。右偏棱镜适应（RPA）主要用作控制条件，因为它不调节健康个体的行为。由于LPA诱导了一个巨大的视觉空间偏差的结果，左半球的调制，和更高的多巴胺能活动在左半球与奖励事件的偏好，我们假设，LPA会增加奖励学习的偏好。健康志愿者在LPA或RPA之前和之后执行基于计算机的概率分类任务。与我们的预测一致，PA改变了奖励与惩罚学习的偏好，LPA组表现出更多的奖励学习。这些结果表明，PA调制多巴胺能活性在一个偏侧的方式。
Visuospatial cognition has an inherent lateralized bias. Individual differences in the direction and magnitude of this bias are associated with asymmetrical D2/3 dopamine binding and dopamine system genotypes. Dopamine level affects feedback-based learning and dopamine signaling asymmetry is related to differential learning from reward and punishment. High D2 binding in the left hemisphere is associated with preference for reward. Prism adaptation (PA) is a simple sensorimotor technique, which modulates visuospatial bias according to the direction of the deviation. Left-deviating prism adaptation (LPA) induces rightward bias in healthy subjects. It is therefore possible that the right side of space increases in saliency along with left hemisphere dopaminergic activity. Right-deviating prism adaptation (RPA) has been used mainly as a control condition because it does not modulate behavior in healthy individuals. Since LPA induces a rightward visuospatial bias as a result of left hemisphere modulation, and higher dopaminergic activity in the left hemisphere is associated with preference for rewarding events we hypothesized that LPA would increase the preference for learning with reward. Healthy volunteers performed a computer-based probabilistic classification task before and after LPA or RPA. Consistent with our predictions, PA altered the preference for rewarded versus punished learning, with the LPA group exhibiting increased learning from reward. These results suggest that PA modulates dopaminergic activity in a lateralized fashion.
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影响因子：
5.3
作者：
Crottaz-Herbette, Sonia;Fornari, Eleonora;Clarke, Stephanie
通讯作者：
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影响因子：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1104047108
发表时间：
2011-06-21
影响因子：
11.1
作者：
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通讯作者：
Yantis, Steven
DOI：
10.1017/s1355617710000597
发表时间：
2010-09-01
影响因子：
2.6
作者：
Goedert, Kelly M.;Leblanc, Andrew;Barrett, Anna M.
通讯作者：
Barrett, Anna M.