IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis.
IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis.
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DOI：
10.5021/ad.2011.23.4.468
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发表时间：
2011-11
影响因子：
1.6
通讯作者：
Yang JM
中科院分区：
文献类型：
--
作者：
Kim S;Kim HJ;Yang HS;Kim E;Huh IS;Yang JM
严重瘙痒是特应性皮炎(AD)的主要症状。最近，新的细胞因子IL-31被认为与AD相关的瘙痒有关。我们进行了这项研究，以确定AD患者血清IL-31水平是否升高，并更好地表征血清IL-31水平与其他已建立的实验室参数之间的关系。我们招募了55名AD患者，34名过敏型AD患者和21名非过敏型AD患者，以及38名健康的非特应性对照组。我们检查了所有患者和对照组的实验室指标、严重程度评分和血清IL-31水平，并检测了13例AD患者和4名对照组皮损中IL-31mRNA的水平。AD患者血清IL-31水平显著升高，其水平与血清IgE、疾病严重程度和主观瘙痒强度有关。AD患者皮损中IL-31mRNA水平与血清IL-31mRNA水平呈正相关。IL-31可能是导致AD炎症和瘙痒的众多介质之一。尽管我们有限的样本量使我们无法做出任何确定的结论，但我们的数据显示，IL-31mRNA水平和血清IL-31蛋白水平之间存在着很强的相关性，这是以前从未报道过的。此外，我们还发现AD患者血清IL-31水平与血清IgE、嗜酸性粒细胞阳离子蛋白、疾病严重程度和受试者瘙痒强度有一定的相关性。
Severe pruritus is the primary symptom in atopic dermatitis (AD). Recently, the novel cytokine IL-31 has been implicated in the itching associated with AD. We performed this study to determine whether IL-31 serum levels are elevated in AD patients and to better characterize the relationship between serum IL-31 level and other established laboratory parameters. We recruited 55 AD patients, 34 with allergic type AD and 21 with non-allergic type AD, and 38 healthy, non-atopic controls. We checked the laboratory values, severity score, and serum IL-31 levels in all patients and controls, and IL-31 mRNA levels in lesion skin were measured in 13 subjects with AD and in four controls. AD patients displayed significantly higher levels of serum IL-31 that were associated with serum IgE, disease severity, and subjective itch intensity. In AD patients, IL-31 mRNA levels from the lesional skin samples also correlated with serum IL-31 level. IL-31 is likely one of the many mediators inducing inflammation and pruritus in AD. Although our limited sample size prevents us from making any definitive conclusions, our data demonstrate a strong correlation between IL-31 mRNA level and serum IL-31 protein level, which has never been reported before. Moreover, we found correlations between serum IL-31 level and serum IgE, eosinophil cationic protein, disease severity, and subject itch intensity in certain degrees in AD patients.
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影响因子：
10.3
作者：
Rho, NK;Kim, WS;Yang, JM
通讯作者：
Yang, JM
影响因子：
6.1
作者：
Jeong, CW;Ahn, KS;Yang, JM
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Yang, JM
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14.2
作者：
Bilsborough, J;Leung, DYM;Gross, JA
通讯作者：
Gross, JA
影响因子：
14.2
作者：
Neis, Mark M.;Peters, Bettina;Hermanns, Heike M.
通讯作者：
Hermanns, Heike M.
影响因子：
14.2
作者：
Schulz, Florian;Marenholz, Ingo;Lee, Young-Ae
通讯作者：
Lee, Young-Ae