Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS?
Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS?
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DOI：
10.1016/j.schres.2017.09.020
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发表时间：
2018-05
影响因子：
4.5
通讯作者：
Corlett PR
中科院分区：
文献类型：
--
作者：
Taylor JJ;Krystal JH;D'Souza DC;Gerrard JL;Corlett PR
精神分裂症和其他精神疾病中幻听（AH）的衰弱和难治性刺激了针对与之相关的异常神经网络的神经调节干预的研究。内部或侵入性形式的脑刺激，如脑深部电刺激（DBS）目前正在探索治疗难治性精神分裂症。开发和实施DBS的过程受到精神病学结构内症状聚集以及缺乏因果工具来预测反应、细化靶向或指导临床决策的限制。经颅磁刺激（TMS），一种外部或非侵入性形式的脑刺激，已显示出作为AH的治疗干预的一些前景，但作为临床相关神经网络的研究探针仍然相对未得到充分利用。在这篇社论中，我们提出TMS有可能通过向患者的评价过程中添加个体化的因果证据来告知DBS。尽管DBS存在显著的局限性和安全性问题，但TMS与神经成像和神经生理数据的计算建模相结合，可以为更强大和适应性更强的网络调制提供关键见解。
The debilitating and refractory nature of auditory hallucinations (AH) in schizophrenia and other psychiatric disorders has stimulated investigations into neuromodulatory interventions that target the aberrant neural networks associated with them. Internal or invasive forms of brain stimulation such as deep brain stimulation (DBS) are currently being explored for treatment-refractory schizophrenia. The process of developing and implementing DBS is limited by symptom clustering within psychiatric constructs as well as a scarcity of causal tools with which to predict response, refine targeting or guide clinical decisions. Transcranial magnetic stimulation (TMS), an external or non-invasive form of brain stimulation, has shown some promise as a therapeutic intervention for AH but remains relatively underutilized as an investigational probe of clinically relevant neural networks. In this editorial, we propose that TMS has the potential to inform DBS by adding individualized causal evidence to an evaluation processes otherwise devoid of it in patients. Although there are significant limitations and safety concerns regarding DBS, the combination of TMS with computational modeling of neuroimaging and neurophysiological data could provide critical insights into more robust and adaptable network modulation.
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影响因子：
6.6
作者：
Alderson-Day B;Diederen K;Fernyhough C;Ford JM;Horga G;Margulies DS;McCarthy-Jones S;Northoff G;Shine JM;Turner J;van de Ven V;van Lutterveld R;Waters F;Jardri R
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影响因子：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
4.5
作者：
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通讯作者：
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影响因子：
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