Induction of Fos expression in the rat brain after intragastric administration of dried bonito dashi
Induction of Fos expression in the rat brain after intragastric administration of dried bonito dashi
复制标题
干鲣鱼高汤灌胃后诱导大鼠脑内 Fos 表达
DOI：
10.1080/1028415x.2019.1670925
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发表时间：
2019
影响因子：
3.6
通讯作者：
Ueta Yoichi
中科院分区：
文献类型：
--
作者：
Kondoh Takashi;Yoshimura Mitsuhiro;Sonoda Satomi;Fujihara Hiroaki;Matsunaga Tetsuro;Ueta Yoichi
目的：干鲣鱼汤是一种传统的日本鱼汤，由干鲣鱼制成，由于其独特的鲜味特征，可提高食物的适口性。然而，模式的大脑激活followingdashiinguperadic.Methods：我们映射的激活位点后，大鼠大脑胃内负荷干bonitodashiFos蛋白，神经元activation.Results的功能标志物的神经元水平的测量，intragastricdashi管理产生增强的Fos表达在四个前脑区域：内侧视前区，穹窿下器官，缰核，中央核的杏仁核。有趣的是，内侧视前区被发现是唯一的喂养相关的下丘脑区域响应dashi管理。此外，达什对延髓核和腹侧被盖区没有影响，这两个相连的部位被高度可口的糖和脂肪激活。在后脑，dashiadministration产生增强的Fos表达在内脏感觉（孤束核尾侧，背侧臂旁核的一部分，和最后区）和自主神经（头端腹外侧延髓，尾侧腹外侧延髓）sites.Discussion：结果表明离散前脑和后脑区域的激活后，胃内负荷干bonitodashi。我们的数据表明，肠-脑轴是与摄入大石相关的摄食后效应的主要介质。
Objectives:Dried bonitodashi, a traditional Japanese fish broth made from dried bonito tuna, enhances food palatability due to its specific umami flavor characteristics. However, the pattern of brain activation followingdashiingestion has not been previously investigated.Methods:We mapped activation sites of the rat brain after intragastric loads of dried bonitodashiby measuring neuronal levels of the Fos protein, a functional marker of neuronal activation.Results:Compared to intragastric saline, intragastricdashiadministration produced enhanced Fos expression in four forebrain regions: the medial preoptic area, subfornical organ, habenular nucleus, and central nucleus of the amygdala. Interestingly, the medial preoptic area was found to be the only feeding-related hypothalamic area responsive todashiadministration. Moreover,dashihad no effect in the nucleus accumbens and ventral tegmental area, two connected sites known to be activated by highly palatable sugars and fats. In the hindbrain,dashiadministration produced enhanced Fos expression in both visceral sensory (caudal nucleus of the solitary tract, dorsal part of the lateral parabrachial nucleus, and area postrema) and autonomic (rostral ventrolateral medulla, and caudal ventrolateral medulla) sites.Discussion:The results demonstrate the activation of discrete forebrain and hindbrain regions following intragastric loads of dried bonitodashi. Our data suggest that the gut–brain axis is the principal mediator of the postingestive effects associated with the ingestion ofdashi.
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DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
T. Kondoh;K. Torii
通讯作者：
K. Torii
摄入用糊精溶液调味的干鲣鱼汤诱导小鼠条件性位置偏好
DOI：
10.1271/bbb.110388
发表时间：
2011
期刊：
Bioscience, Biotechnology, and Biochemistry
影响因子：
--
作者：
Hiroya Kawasaki;Atsuko Yamada;Ryota Fuse;T. Fushiki
通讯作者：
T. Fushiki
影响因子：
2
作者：
Kondoii, Takashi;Torii, Kunio
通讯作者：
Torii, Kunio
对胃肠营养刺激的神经反应机制：肠脑轴。
影响因子：
29.4
作者：
T. Tsurugizawa;A. Uematsu;E. Nakamura;M. Hasumura;M. Hirota;T. Kondoh;H. Uneyama;K. Torii
通讯作者：
K. Torii
影响因子：
2.5
作者：
NORGREN, R
通讯作者：
NORGREN, R